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Polymyxin B . sulfate

PKC inhibitor
ALX-380-040-G001 1 g 91.00 USD
ALX-380-040-G005 5 g 330.00 USD
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Antibiotic. Inhibitor of protein kinase C (PKC). Breaks the bacterial membrane by incorporating into the phospholipid of the outer membrane and activating phospholipase.

Product Details

MI:14: 7573
Purity:≥80% (HPLC) (sum of polymyxins B1, B2, B3, B1-I)
Purity Detail:Mixture of Polymyxin B1, B2, B3 and B1-I.
Appearance:White to off-white powder.
Solubility:Soluble in water (50mg/ml).
Shipping:Ambient Temperature
Long Term Storage:+4°C
Regulatory Status:RUO - Research Use Only
Polymyxin B1
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Product Literature References

Immune activation of vaginal human Langerhans cells increases susceptibility to HIV-1 infection: N.H.V. Teijlingen, et al.; Sci. Rep. 13, 3283 (2023), Abstract;
The effect of temperature and heat shock protein 72 on the ex vivo acute inflammatory response in monocytes: S.P. Hoekstra, et al.; Cell Stress Chaperones 24, 461 (2019), Application(s): experimental treatement- human male blood, Abstract;
Modulation of P2X7 receptor functions by polymyxin B: crucial role of the hydrophobic tail of the antibiotic molecule: D. Ferrari, et al.; Br. J. Pharmacol. 150, 445 (2007), Abstract;
Polymyxin antibiotics for gram-negative infections: T. M. Arnold, et al.; Am. J. Health Syst. Pharm. 64, 819 (2007), Review, Abstract;
Direct effects of polymyxin B on human dendritic cells maturation. The role of IkappaB-alpha/NF-kappaB and ERK1/2 pathways and adhesion: B. Valentinis, et al.; J. Biol. Chem. 280, 14264 (2005), Abstract;
Gap junctional conductance tunes phase difference of cholecystokinin evoked calcium oscillations in pairs of pancreatic acinar cells: A. Ngezahayo & H.A. Kolb; Pfluegers Arch. 422, 413 (1993), Abstract;
Inhibitors such as staurosporine, H-7 or polymyxin B cannot be used in skeletal muscle to prove the role of protein kinase C on insulin action: A. Guma, et al.; Biosci. Rep. 12, 413 (1992), Abstract;
Volume-regulatory Cl- channel currents in cultured human epithelial cells: M. Kubo & Y. Okada; J. Physiol. 456, 351 (1992), Abstract;
Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B & cardiotoxin. Differential inhibition of PKC, CaMKII & synaptosomal membrane Na,K-ATPase & Na+ pump & differentiation of HL60 cells.: R.L. Raynor, et al.; J. Biol. Chem. 266, 2753 (1991), Abstract; Full Text
Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine: C. Schächtele, et al.; BBRC 151, 542 (1988), Abstract;