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F-ATPase inhibitor
ALX-380-037-M005 5 mg 109.00 USD
ALX-380-037-M010 10 mg 190.00 USD
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Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1), preventing phosphoryl group transfer. Induces apoptosis.

Product Details

MW:791.1 (Oligomycin A)
Source:Isolated from Streptomyces diastatochromogens.
MI:14: 6833
Purity:≥90% (HPLC, TLC)
Purity Detail:Mixture of oligomycin A (major component), B, and C.
Appearance:White to faint yellow powder.
Solubility:Soluble in 100% ethanol, methanol (10mg/ml) or acetone (50mg/ml).
Shipping:Ambient Temperature
Long Term Storage:+4°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Fluorescence imaging detection of nanodomain redox signaling events at organellar contacts: D.M. Booth, et al.; STAR Protoc. 3, 101119 (2022), Abstract; Full Text
Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER: D.M. Booth, et al.; Mol. Cell 81, 3866 (2021), Abstract; Full Text
Differentiating SGBS adipocytes respond to PPARγ stimulation, irisin and BMP7 by functional browning and beige characteristics: A. Klusoczki, et al.; Sci. Rep. 9, 5823 (2019), Abstract; Full Text
Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen: M. Deygas, et al.; Nat. Commun. 9, 4545 (2018), Abstract; Full Text
UBXD1 is a mitochondrial recruitment factor for p97/VCP and promotes mitophagy: A.C. Bento, et al.; Sci. Rep. 8, 12415 (2018), Abstract; Full Text
Time courses of post-injury mitochondrial oxidative damage and respiratory dysfunction and neuronal cytoskeletal degradation in a rat model of focal traumatic brain injury: R.L. Hill, et al.; Neurochem. Int. 111, 45 (2017), Abstract;
The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions: S. Koob, et al.; Biochim. Biophys. Acta 1853, 1551 (2015), Application(s): Cell Culture, Abstract;
Microautophagy of the nucleus coincides with a vacuolar diffusion barrier at nuclear-vacuolar junctions: R. Dawaliby, et al.; Mol. Biol. Cell 21, 4173 (2010), Abstract; Full Text
Apoptosis in factor-dependent haematopoietic cells is linked to calcium- sensitive mitochondrial rearrangements and cytoskeletal modulation: J. Garland, et al.; Br. J. Haematol. 109, 221 (2000), Abstract;
Properties of DNA fragmentation activity generated by ATP depletion: N. Nakamura & Y. Wada; Cell Death Differ. 7, 477 (2000), Abstract;
Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of the apoptotic program: J. Zhuang, et al.; J. Biol. Chem. 273, 15628 (1998), Abstract; Full Text
Mitochondrial respiratory chain inhibitors induce apoptosis: E.J. Wolvetang, et al.; FEBS Lett. 339, 40 (1994), Abstract;
Cyclosporin A suppression of uncoupling in liver mitochondria of ground squirrel during arousal from hibernation: N.N. Brustovetsky, et al.; FEBS Lett. 315, 233 (1993), Abstract;
Inhibition of the Na(+)-Ca++ exchanger enhances anoxia and glucopenia- induced [3H]aspartate release in hippocampal slices: S. Amoroso, et al.; J. Pharmacol. Exp. Ther. 264, 515 (1993), Abstract;
The lipophilic weak base (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4- piperidinopyridine (AU-1421) is a potent protonophore type cationic uncoupler of oxidative phosphorylation in mitochondria: H. Nagamune, et al.; Biochim. Biophys. Acta 1141, 231 (1993), Abstract;

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