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Neomycin . sulfate

Inhibitor of PLC and PLD



ALX-380-035-G025	25 g	460.00 USD
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Replaces Prod. #: BML-EI180

Aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes. Inhibitor of phospholipase C (PLC; IC₅₀=1-10µM) due to binding to inositol phospholipids. Neomycin inhibits phosphatidylcholine-phospholipase D activity (IC₅₀=65µM). Blocks voltage sensitive Ca²⁺ channels without affecting Na⁺/Ca²⁺ antiporters in nerve cells. Induces PLA2 activation in human platelets.

Product Details

Formula:	C₂₃H₄₆N₆O₁₃ . 3H₂SO₄

MW:	614.7 . 294.2

CAS:	1405-10-3

MI:	14: 6454

RTECS:	QP4375000

Purity:	≥90% (TLC)

Appearance:	White to off-white solid.

Solubility:	Soluble in water (10mg/ml).

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Handling:	Protect from light and moisture.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Impact of MyD88, Microbiota, and Location on Type 1 and Type 3 Innate Lymphoid Cells during Toxoplasma gondii Infection: L.M. Snyder, et al.; Immunohorizons 6, 660 (2022), Abstract;

Induction of IL-12p40 and type 1 immunity by Toxoplasma gondii in the absence of the TLR-MyD88 signaling cascade: L.M. Snyder, et al.; PLoS Pathog. 17, e1009970 (2021), Abstract;

Air bubble contact with endothelial cells in vitro induces calcium influx and IP3-dependent release of calcium stores: P. Sobolewski, et al.; Am. J. Physiol. Cell Physiol. 301, C679 (2011), Abstract;

Elimination of plasma membrane phosphatidylinositol (4,5)-bisphosphate is required for exocytosis from mast cells: G.R. Hammond, et al.; J. Cell Sci. 119, 2084 (2006), Abstract; Full Text

Neomycin inhibits glioma cell migration: P. Cuevas, et al.; Neurol. Res. 26, 273 (2004), Abstract;

Antiproliferative action of neomycin is associated with inhibition of cyclin D1 activation in glioma cells: P. Cuevas, et al.; Neurol. Res. 25, 961 (2003), Abstract;

Nerve extracts and substance P activate the phosphatidylinositol signaling pathway and mitogenesis in newt forelimb regenerates: M.J. Smith, et al.; Dev. Biol. 167, 239 (1995), Abstract;

Neomycin inhibition of hormone-stimulated smooth muscle contractions in myometrial tissue: M. Philippe; BBRC 205, 245 (1994), Abstract;

Gadolinium and neomycin block voltage-sensitive Ca2+ channels without interfering with the Na(+)-Ca2+ antiporter in brain nerve endings: L.M. Canzoniero, et al.; Eur. J. Pharmacol. 245, 97 (1993), Abstract;

Inhibition of neural phospholipase D activity by aminoglycoside antibiotics: M. Liscovitch, et al.; Biochem. J. 279, 319 (1991), Abstract;

Binding of neomycin to phosphatidylinositol 4,5-bisphosphate (PIP2): E. Gabev, et al.; Biochim. Biophys. Acta 979, 105 (1989), Abstract;

Neomycin is a potent agent for arachidonic acid release in human platelets: S. Nakashima, et al.; BBRC 146, 820 (1987), Abstract;

Inositol 1,4,5-trisphosphate: a possible chemical link in excitation- contraction coupling in muscle: J. Vergara, et al.; PNAS 82, 6352 (1985), Abstract;

Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation: D.H. Carney, et al.; Cell 42, 479 (1985), Abstract;

Effects of neomycin on calcium and polyphosphoinositide metabolism of guinea pig synaptosomes: H.D. Griffin, et al.; J. Neurochem. 34, 750 (1980), Abstract;