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Apoptosis inducer. Protein kinase inhibitor.
ALX-380-014-C100 100 µg 62.00 USD
ALX-380-014-C250 250 µg 122.00 USD
ALX-380-014-M001 1 mg 307.00 USD
ALX-380-014-M005 5 mg 428.00 USD
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Replaces Prod. #: BML-EI156

Model apoptosis inducer. Potent cell-permeable inhibitor of a variety of protein kinases, e.g. protein kinase C (PKC), CDK1/cyclin B (IC50~5nM), CDK2/cyclin A (IC50=7nM), CDK4/cyclin D (IC50=3-10µM), CDK5/p25 (IC50=4nM), GSK-3β (IC50=15nM), Pim-1 kinase (IC50=10nM).Binds do the ATP binding domain. Did not inhibit PKC-ζ. At 1µM induced apoptosis in CHO cells. Inhibits topoisomerase II directly by blocking transfer of phosphodiester bonds from DNA to active site tyrosine.

Product Details

Alternative Name:Antibiotic AM-2282
Source:Isolated from Streptomyces staurosporeus.
MI:14: 8802
Purity:≥99% (HPLC)
Appearance:Off-white to green powder.
Solubility:Soluble in ethyl acetate, DMSO (25mg/ml) or dimethyl formamide (25mg/ml); only slightly soluble in chloroform and methanol. Insoluble in water.
Long Term Storage:+4°C
Use/Stability:Stable for at least 2 years after receipt when stored +4°C.
Handling:Protect from light and moisture. Store under inert gas.
Technical Info/Product Notes:Replacement for ADI-HPK-112
Regulatory Status:RUO - Research Use Only
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Product Literature References

Helicobacter pylori-induced reactive oxygen species direct turnover of CSN-associated STAMBPL1 and augment apoptotic cell death: S. Chaithongyot & M. Naumann; Cell. Mol. Life Sci. 79, 86 (2022), Abstract;
Apoptotic Extracellular Vesicles Ameliorate Multiple Myeloma by Restoring Fas-Mediated Apoptosis: J. Wang, et al.; ACS Nano 15, 14360 (2021), Abstract;
Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells: D. Bloemberg & J. Quadilatero; J. Cell. Physiol. 236, 3099 (2021), Application(s): Mouse skeletal myoblasts (C2C12) treatment, Abstract;
Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease: J. Hey, et al.; Nat. Commun. 12, 6520 (2021), Abstract;
Staurosporine-induced cleavage of apoptosis-inducing factor in human fibrosarcoma cells is independent of matrix metalloproteinase-2: W. Bassiouni, et al.; Can. J. Physiol. Pharmacol. (2021), Abstract;
Divergent effects of canonical and non-canonical TGF-β signalling on mixed contractile-synthetic smooth muscle cell phenotype in human Marfan syndrome aortic root aneurysms: A.J. Pedroza, et al.; J. Cell. Mol. Med. 24, 2369 (2020), Abstract; Full Text
Kinase-Based Screening of Marine Natural Extracts Leads to the Identification of a Cytotoxic High Molecular Weight Metabolite from the Mediterranean Sponge Crambe tailliezi: T.N. Nguyen, et al.; Mar. Drugs 17, 569 (2019), Abstract; Full Text
Loss of Peter Pan (PPAN) Affects Mitochondrial Homeostasis and Autophagic Flux: D.P. Dannheisig, et al.; Cells 8, 894 (2019), Abstract; Full Text
Membrane Localization of HspA1A, a Stress Inducible 70-kDa Heat-Shock Protein, Depends on Its Interaction with Intracellular Phosphatidylserine: A.D. Bilog, et al.; Biomolecules 9, 152 (2019), Abstract; Full Text
Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells: S. Zielke, et al.; Cell Death Dis. 9, 994 (2018), Abstract; Full Text
Cobalamin-Associated Superoxide Scavenging in Neuronal Cells Is a Potential Mechanism for Vitamin B12-Deprivation Optic Neuropathy: W. Chan, et al.; Am. J. Pathol. 188, 160 (2017), Abstract;
Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages: C.Y. Taabazuing, et al.; Cell Chem. Biol. 24, 507 (2017), Abstract; Full Text
The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway: A.S. Pfister, et al.; J. Biol. Chem. 290, 10905 (2017), Abstract; Full Text
Artesunate induces ROS-dependent apoptosis via a Bax-mediated intrinsic pathway in Huh-7 and Hep3B cells: Y. Pang, et al.; Exp. Cell Res. 16, 30161 (2016), Application(s): Flow cytometry analysis, Abstract;
Genetically encoded far-red fluorescent sensors for caspase-3 activity: O.A. Zlobovskaya, et al.; Biotechniques. 60, 62 (2016), Application(s): Induced apoptosis, Abstract; Full Text
Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers: L.D. Goldstein, et al.; Cell Rep. 16, 2605 (2016), Application(s): Cell Viability and DNA Fragmentation Analysis, Abstract;
Targeting of nucleotide-binding proteins by HAMLET-a conserved tumor cell death mechanism: J.C. Ho, et al.; Oncogene 35, 897 (2016), Application(s): Cell Culture, Abstract;
Triggering of Suicidal Erythrocyte Death by Bexarotene: A. Al Mamun Bhuyan, et al.; Cell. Physiol. Biochem. 40, 1239 (2016), Abstract;
A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial associated necrosis in breast cancer: A. Bastian, et al.; J. Pharmacol. Exp. Ther. 353, 392 (2015), Application(s): Western Blotting, Abstract; Full Text
Artesunate induces apoptosis via a ROS-independent and Bax-mediated intrinsic pathway in HepG2 cells: G. Qin, et al.; Exp. Cell Res. 336, 308 (2015), Application(s): Cell Culture, Abstract;
Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101).: J. Mani, et al.; BMC Cancer 15, 224 (2015), Application(s): Cell Culture, Abstract; Full Text
The Wnt target Peter Pan defines a novel p53-independent nucleolar stress response pathway: A.S. Pfister, et al.; J. Biol. Chem. 290, 10905 (2015), Application(s): Cell Culture, Abstract; Full Text
Prolyl-4-hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions: L. Swain, et al.; J. Leukoc. Biol. 96, 365 (2014), Abstract;
Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism: N.M. Chumbler, et al.; PLoS Pathog. 8, e1003072 (2012), Abstract; Full Text
Distinct roles of mitochondria- and ER-localized Bcl-xL in apoptosisresistance and Ca2+ homeostasis: C.O. Eno, et al.; Mol. Biol. Cell. 23, 2605 (2012), Abstract; Full Text
Staurosporine and cytochalasin D induce chondrogenesis by regulation of actin dynamics in different way: M. Kim, et al.; Exp. Mol. Med. 44, 521 (2012), Abstract; Full Text
Curcumin attenuates staurosporine-mediated death of retinal ganglion cells: B. Burugula, et al.; Invest. Ophthalmol. Vis. Sci. 52, 4263 (2011), Abstract; Full Text
FKBP51 protects 661w cell culture from staurosporine-induced apoptosis: D.R. Daudt & T. Yorio; Mol. Vis. 17, 1172 (2011), Abstract; Full Text
Neuronal differentiation by analogs of staurosporine: A.F. Thompson & L.A. Levin; Neurochem. Int. 56, 554 (2010), Abstract; Full Text
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases: M. Rebsamen, et al.; Cell Death Differ. 15, 1804 (2008), Abstract;
The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP: J.J. Goval, et al.; Haematologica 93, 1169 (2008), Abstract; Full Text
Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002: M.D. Jacobs, et al.; J. Biol. Chem. 280, 13728 (2005), Abstract;
Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3: M. Rehm, et al.; J. Biol. Chem. 277, 24506 (2002), Abstract; Full Text
Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase: M.M. Hill, et al.; J. Biol. Chem. 276, 25643 (2001), Abstract; Full Text
Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis: D. Tang, et al.; J. Biol. Chem. 275, 9303 (2000), Abstract; Full Text
Changes in mitochondrial membrane potential during staurosporine- induced apoptosis in Jurkat cells: J.L. Scarlett, et al.; FEBS Lett. 475, 267 (2000), Abstract;
Dissociation of staurosporine-induced apoptosis from G2-M arrest in SW620 human colonic carcinoma cells: initiation of the apoptotic cascade is associated with elevation of the mitochondrial membrane potential (deltapsim): B.G. Heerdt, et al.; Cancer Res. 60, 6704 (2000), Abstract;
Equivalent death of P-glycoprotein expressing and nonexpressing cells induced by the protein kinase C inhibitor staurosporine: K.M. Tainton, et al.; BBRC 276, 231 (2000), Abstract;
Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium: G.N. Bijur, et al.; J. Biol. Chem. 275, 7583 (2000), Abstract; Full Text
Molecular mechanism of staurosporine-induced apoptosis in osteoblasts: H.J. Chae, et al.; Pharmacol. Res. 42, 373 (2000), Abstract;
Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c: D.G. Kirsch, et al.; J. Biol. Chem. 274, 21155 (1999), Abstract; Full Text
Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines: J. Boix, et al.; Neuropharmacology 36, 811 (1997), Abstract;
Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis: X. Wang et al.; EMBO J. 15, 1012 (1996), Abstract;
K252a and staurosporine microbial alkaloid toxins as prototype of neurotropic drugs: P. Lazarovici, et al.; Adv. Exp. Med. Biol. 391, 367 (1996), Review, Abstract;
Mechanism of topoisomerase II inhibition by staurosporine and other protein kinase inhibitors: P. Lassota et al.; J. Biol. Chem. 271, 26418 (1996), Abstract;
Staurosporine and ent-staurosporine: the first total synthesis, prospects for a regioselective approach, and activity profile: J.T. Link et al.; J. Am. Chem. Soc. 118, 2825 (1996),
Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway: D.A. Wiesner & G. Dawson; J. Neurochem 66, 1418 (1996), Abstract;
First total synthesis of Staurosporine and ent-Staurosporine: J.T. Link et al.; J. Am. Chem. Soc. 117, 552 (1995),
Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue: C.M Seynaeve et al.; Mol. Pharmacol. 45, 1207 (1994), Abstract;
Induction of a common pathway of apoptosis by staurosporine: R. Bertrand, et al.; Exp. Cell Res. 211, 314 (1994), Abstract;
Is staurosporine a specific inhibitor of protein kinase C in intact porcine coronary arteries?: M. Kageyama, et al.; J. Pharmacol. Exp. Ther. 259, 1019 (1991), Abstract;
Staurosporine: an effective inhibitor for Ca2+/calmodulin-dependent protein kinase II: N. Yanagihara, et al.; J. Neurochem. 56, 294 (1991), Abstract;
Staurosporine, a protein kinase C inhibitor interferes with proliferation of arterial smooth muscle cells: H. Matsumoto & Y. Sasaki; Biochem. Biophys. Res. Commun. 158, 105 (1989), Abstract;
Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases: U.T. Ruegg & G.M. Burgess; TIPS 10, 218 (1989), (Review), Abstract;
Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells: T. Sako, et al.; Cancer Res. 48, 4646 (1988), Abstract;
Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60: N. Nakano, et al.; J. Antibiot. (Tokyo) 40, 706 (1987), Abstract;
Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase: T. Tamaoki, et al.; BBRC 135, 397 (1986), Abstract;
Staurosporine, a potent platelet aggregation inhibitor from a Streptomyces species: S. Oka, et al.; Agric. Biol. Chem. 50, 2723 (1986),
A. Furusaki, et al.; J. C. S. Chem. Commun. 800 (1978),
A new alkaloid AM-2282 of Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization: S. Omura, et al.; J. Antibiot. (Tokyo) 30, 275 (1977), Abstract;

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