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ALX-380-008-M001 1 mg 45.00 USD
ALX-380-008-M005 5 mg 90.00 USD
ALX-380-008-M025 25 mg 286.00 USD
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Replaces Prod. #: BML-A235

Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK506 binding protein and to inhibit the Ca2+-dependent phosphatase and protein phosphatase 2B (PP2B; calcineurin). Activates NF-κB through phosphorylation and degradation of IκBα.

Product Details

Alternative Name:Tacrolimus
Source:Isolated from Streptomyces tsukubaensi.
MI:14: 9025
Purity:≥98% (HPLC)
Appearance:White to off-white crystalline powder.
Solubility:Soluble in DMSO, 100% ethanol, methanol, ethyl acetate or acetone; insoluble in water.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Specification of skeletal muscle fiber-type is determined by the calcineurin/NFATc1 signaling pathway during muscle regeneration: J. Shin, et al.; Biochem. Biophys. Res. Commun. 659, 20 (2023), Abstract;
Zebrafish Larvae Position Tracker (Z-LaP Tracker): a high-throughput deep-learning behavioral approach for the identification of calcineurin pathway-modulating drugs using zebrafish larvae: S.V. Gore, et al.; Sci. Rep. 13, 3174 (2023), Abstract;
Dynamic changes in β-cell [Ca 2+] regulate NFAT activation, gene transcription, and islet gap junction communication: J.G. Miranda, et al.; Mol. Metab. 57, 101430 (2022), Abstract;
Fluorescence imaging detection of nanodomain redox signaling events at organellar contacts: D.M. Booth, et al.; STAR Protoc. 3, 101119 (2022), Abstract; Full Text
Novel use of FDA-approved drugs identified by cluster analysis of behavioral profiles: S.T. Edmister, et al.; Sci. Rep. 12, 6120 (2022), Abstract;
Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER: D.M. Booth, et al.; Mol. Cell 81, 3866 (2021), Abstract; Full Text
Safety and efficacy of tacrolimus-coated silicone plates as an alternative to mitomycin C in a rabbit model of conjunctival fibrosis: S.Y. Yoon, et al.; PLoS One 14, e0219194 (2019), Abstract; Full Text
Calcineurin A beta deficiency ameliorates HFD-induced hypothalamic astrocytosis in mice: K. Pfuhlmann, et al.; J. Neuroinflammation 15, 35 (2018), Abstract; Full Text
Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer’s Disease: M. Asai, et al.; Biol. Pharm. Bull. 39, 1646 (2016), Application(s):, Abstract; Full Text
Tacrolimus Modulates TGF-β Signaling to Induce Epithelial-Mesenchymal Transition in Human Renal Proximal Tubule Epithelial Cells: J. Bennett, et al.; J. Clin. Med. 5, 50 (2016), Application(s): Cell treatment, Abstract;
The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia: D.B. Kurland, et al. ; J. Neuroinflammation 13, 130 (2016), Application(s): Cell culture, Abstract; Full Text
Distinct biological activity of threonine monophosphorylated MAPK isoforms during the stress response in fission yeast: B. Vazquez, et al.; Cell. Signal. 27, 2534 (2015), Application(s): Cell Culture, Abstract;
Effects of embryonic cyclosporine exposures on brain development and behavior: D.E. Clift, et al.; Behav. Brain Res. 282, 117 (2015), Application(s): Cell Culture, Abstract;
Feedback Mechanisms Regulate Ets variant 2 (Etv2) Gene Expression and Hematoendothelial Lineages: N. Koyano-Nakagawa, et al.; J. Biol. Chem. 290, 28107 (2015), Application(s): Calcineurin inhibition, Abstract; Full Text
A review of the action of tacrolimus (FK506) on experimental models of rheumatoid arthritis: S. Miyata, et al.; Inflamm. Res. 54, 1 (2005), Review, Abstract;
FK506 and its analogs - therapeutic potential for neurological disorders: A. Klettner and T. Herdegen; Curr. Drug Targets CNS Neurol. Disord. 2, 153 (2003), Review, Abstract;
FK506, an immunosuppressant targeting calcineurin function: F.J. Dumont; Curr. Med. Chem. 7, 731 (2000), Abstract;
Immunosuppressant FK506 activates NF-kappaB through the proteasome-mediated degradation of IkappaBalpha. Requirement for Ikappabalpha n-terminal phosphorylation but not ubiquitination sites: Y. Zhang, et al.; J. Biol. Chem. 274, 34657 (1999), Abstract; Full Text
Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology: B.E. Bierer, et al.; Curr. Opin. Immunol. 5, 763 (1993), Abstract;
Cyclosporin A, FK506 and rapamycin: more than just immunosuppression: J. Kunz and M.N. Hall; TIBS 18, 334 (1993), Abstract;
FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics: T. Kino, et al.; J. Antibiot. (Tokyo) 40, 1249 (1987), Abstract;