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Ponasterone A

ALX-370-014-M001 1 mg 75.00 USD
ALX-370-014-M005 5 mg 269.00 USD
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A member of the ecdysteroid family. Analog of ecdysone with similar properties to muristerone A. It is a functional, reliable and economical substitute for muristerone A as an inducer for the ecdysone-inducible mammalian expression system. Results show that ponasterone A was able to induce expression of β-galactosidase to levels similar to those obtained with muristerone A induction. Potent compound for ecdysteroid activity; EC50= 0.07 µM.

Product Details

Alternative Name:25-Deoxy-20-hydroxyecdysone, 25-Deoxyecdysterone, 2β,3β,14α,20R,22R-Pentahydroxy-5β-cholest-7-en-6-one
MI:14: 7588
Purity:≥95% (HPLC)
Identity:Identity determined by NMR.
Appearance:White to off-white powder.
Solubility:Soluble in acetic acid, 100% ethanol, methanol or DMSO; insoluble in water.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:To prepare a 1mM stock solution (1.1mM) in 100% ethanol: Add 2ml of 100% ethanol to 1mg (2µmol). Gently mix to dissolve the product (5 to 10 min.). Do not heat solution to dissolve the product. Store the 1mM stock solution at +4°C or at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Reconfigurable Hybrid interface for molecular marker diagnostics and in-situ reporting: K. Ehrhardt, et al.; Biosens. Bioelectron. 74, 744 (2015), Application(s): Cell Culture, Abstract;
Development of an in vitro Reporter Gene Assay for Screening the Ecdysone Receptor Agonists in Mysid Crustacean: M. Hirano, et al.; Interdisciplinary Studies on Environmental Chemistry 4, 141 (2010), (Book chapter), Full Text
Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1: M. Cui, et al.; J. Biol. Chem. 285, 11740 (2010), Abstract; Full Text
Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth: L. Nardinocchi, et al.; Biochim. Biophys. Acta 1793, 368 (2009), Abstract;
Development of a ponasterone A-inducible gene expression system for application in cultured skeletal muscle cells: Y.Y. Xiao, et al.; Int. J. Biochem. Cell. Biol. 35, 79 (2003), Abstract;
Recent advances in inducible expression in transgenic mice: C. Albanese, et al.; Semin. Cell. Dev. Biol. 13, 129 (2002), Abstract;
Identification of ligands and coligands for the ecdysone-regulated gene switch: E. Saez, et al.; PNAS 97, 14512 (2000), Abstract;
Past and present studies with ponasterones, the first insect molting hormones from plants: K. Nakanishi; Steroids 57, 649 (1992), Abstract;
The uptake and release of ponasterone A by the Kc cell line of Drosophila melanogaster: C. Beckers, et al.; Mol. Cell. Endocrinol. 17, 51 (1980), Abstract;
Extraction of ponasterone A and ecdysterone from podocarpaceae and related plants: S. Imai et al.; Steroids 10, 557 (1967), Abstract;

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