Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Pristimerin

Antitumor agent
 
ALX-350-411-M005 5 mg 159.00 USD
 
ALX-350-411-M025 25 mg 647.00 USD
Do you need bulk/larger quantities?
 
Triterpenoid. Antitumor agent. Induces caspase-dependent apoptosis by inhibiting the chymotrypsin-like activity of the proteasome. Inhibits NF-κB activation via inhibition of IKKα or IKKβ. Inhibits induction of inducible nitric oxide synthase (iNOS; NOS II). Shows in vitro antimalarial and insecticidal activity. Induces mitochondrial cell death. Has antiproliferative, antifungal and antiviral properties. Potent and reversible monoacylglycerol lipase (MGL) inhibitor.

Product Specification

Alternative Name:Celastrol methyl ester
 
Formula:C30H40O4
 
MW:464.6
 
Source:Isolated from Tripterygium wilfordii Hook.F.
 
CAS:1258-84-0
 
MI:14: 10370
 
Purity:≥97% (HPLC)
 
Identity:Determined by IR.
 
Appearance:Orange crystalline solid.
 
Solubility:Soluble in DMSO or ethyl acetate; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
Regulatory Status:RUO - Research Use Only
 
350-411
Please mouse over
350-411

Product Literature References

Pristimerin Inhibits Prostate Cancer Bone Metastasis by Targeting PC-3 Stem Cell Characteristics and VEGF-Induced Vasculogenesis of BM-EPCs: S. Huang, et al.; Cell. Physiol. Biochem. 37, 253 (2015), Application(s): Cell culture, Abstract; Full Text
Discovery of potent and reversible monoacylglycerol lipase inhibitors: A.R. King, et al.; Chem. Biol. 16, 1045 (2009), Abstract;
Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo: R.E. Tiedemann, et al.; Blood 113, 4027 (2009), Abstract;
Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells: J.Y. Byun, et al.; Mol. Pharmacol. 76, 734 (2009), Abstract;
Triterpenoids as new promising anticancer drugs: A. Petronelli, et al.; Anticancer Drugs 20, 880 (2009), Abstract;
Antiproliferative activity of pristimerin isolated from Maytenus ilicifolia (Celastraceae) in human HL-60 cells: P.M. Costa, et al.; Toxicol. in vitro 22, 854 (2008), Abstract;
Pristimerin induces apoptosis by targeting the proteasome in prostate cancer cells: H. Yang, et al.; J. Cell. Biochem. 103, 234 (2008), Abstract;
Anticytomegalovirus activity of pristimerin, a triterpenoid quinone methide isolated from Maytenus heterophylla (Eckl. & Zeyh.): T. Murayama, et al.; Antivir. Chem. Chemother. 18, 133 (2007), Abstract;
Antigiardial activity of triterpenoids from root bark of Hippocratea excelsa: G.J. Mena-Rejón, et al.; J. Nat. Prod. 70, 863 (2007), Abstract;
Antifungal properties of pristimerin and celastrol isolated from Celastrus hypoleucus: D.Q. Luo, et al.; Pest Manag. Sci. 61, 85 (2005), Abstract;
Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria: C.C. Wu, et al.; Mol. Cancer Ther. 4, 1277 (2005), Abstract; Full Text
Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii: F.R. Chang, et al.; J. Nat. Prod. 66, 1416 (2003), Abstract;
Release of intermediate reactive hydrogen peroxide by macrophage cells activated by natural products: R.R. Moreira, et al.; Biol. Pharm. Bull. 24, 201 (2001), Abstract; Full Text
Insecticidal activity of Maytenus species (Celastraceae) nortriterpene quinone methides against codling moth, Cydia pomonella (L.) (Lepidoptera: tortricidae): J. Avilla, et al.; J. Agric. Food Chem. 48, 88 (2000), Abstract;
Novel quinone methides from Salacia kraussii with in vitro antimalarial activity: J.N. Figueiredo, et al.; J. Nat. Prod. 61, 718 (1998), Abstract;
The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages: V.M. Dirsch, et al.; Eur. J. Pharmacol. 336, 211 (1997), Abstract;
Structure of pristimerin: A.B. Kulkarni & R.C. Shah; Nature 173, 1237 (1954), Abstract;

Related Products

Celastrol 

Anti-inflammatory and immunosuppressive
34157-83-0, Isolated from the root of Tripterygium sp., ≥98% (HPLC) | Print as PDF
 
ALX-350-332-M005 5 mg 86.00 USD
 
ALX-350-332-M025 25 mg 312.00 USD
Do you need bulk/larger quantities?
 

Related Literature

Brochures
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Download as PDF

All new literature pieces

Recommend this page

 
Keep in touch

©2020 Enzo Life Sciences, Inc.,