Alkaloid. Antimitotic / antiproliferative agent. Belongs to a class of biologically active indole alkaloids characterized by a unique spiroaminal framework.The antiproliferative activity against Jurkat cells was evaluated by MTT assay. Has been shown to inhibit cell proliferation in a dose dependent manner with an IC50 value of 43.7µM. After 15-20h of neoxaline treatment (70µM), an accumulation of cells at the G2/M phase was observed, showing that the antiproliferative activity of neoxaline is due to an arrest of the cell cycle at the G2/M phase. Has a weak inhibitory activity on blood platelet aggregation induced by stimulation of the central nervous system.
Product Details
| Alternative Name: | 7a-(1,1-Dimethyl-2-propenyl)-6,7,7a,12-tetrahydro-6-hydroxy-3-(1H-imidazol-4-yl-methylene)-12-methoxy-1H,5H-imidazo[1’,2’:1,2]pyrido[2,3-b]indole-25(3H)dione |
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| Formula: | C23H25N5O4 |
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| MW: | 435.48 |
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| Source: | Isolated from Aspergillus japonicus Fg-551. |
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| CAS: | 71812-10-7 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in acetone, chloroform, ethyl acetate or methanol; insoluble in water or hexane. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Technical Info/Product Notes: | Manufactured with courtesy strain from The Kitasato Institute. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Efficient total synthesis of novel bioactive microbial metabolites.: T. Sunazuka, et al.; Acc. Chem. Res.
41, 302 (2008),
Abstract;
Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization.: Y. Koizumi, et al.; Biochim. Biophys. Acta
1693, 47 (2004),
Abstract;
Oxaline and Neoxaline.: Y Konda, et al.; Chem. Pharm. Bull.
28, 2987 (1980),
Abstract;
Full Text
Neoxaline, a new alkaloid produced by Aspergillus japonicus. Production, isolation and properties.: A. Hirano, et al.; J. Antibiot.
32, 781 (1979),
Abstract;
