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Hydroxytyrosol . acetate

ALX-350-404-M050 50 mg 127.00 USD
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Antioxidant comparable to resveratrol (Prod. No. BML-FR104). Is converted to hydroxytyrosol through hydrolysis by esterases. Reaches full oxygen radical absorbance capacity (ORAC) when converted to free hydoxytyrosol. ORAC values of hydroxytyrosol are about 50% higher than resveratrol, 10-fold higher than L(+)-ascorbic acid and 4-fold higher than (-)-epicatechin. Has been shown to have anticancer and antiviral effects.
Antibacterial at 400µg/mL against Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae.

Product Details

Alternative Name:HTS, 2-(3,4-Dihydroxyphenyl)-ethyl acetate
Purity:≥98% (HPLC)
Appearance:White to off-white powder.
Solubility:Freely soluble in organic solvents; slightly soluble in water (10mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light.
Scientific Background:Hydroxytyrosol-acetate is a small-molecule phenolic compound found in the leaves and fruits of olive (Olea eurolaea). It is a metabolite of oleuropein (Ole), one of the major polyphenolic components of olive products.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells: M. Notarnicola, et al.; Genes Nutr. 6, 63 (2011), Abstract; Full Text
Synergistic antibacterial effects of polyphenolic compounds from olive mill wastewater: A. Tafesh, et al.; Evid. Based Complement. Alternat. Med. 2011, 431021 (2011), Abstract; Full Text
Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells.: J. Han et al.; Cytotechnology 59, 45 (2009), Abstract;
Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1.: G. Corona et al.; JP. Mol. Nutr. Food Res. 53, 897 (2009), Abstract;
Mechanism of the antiviral effect of hydroxytyrosol on influenza virus appears to involve morphological change of the virus.: K. Yamada et al.; Antiviral Res. 83, 35 (2009), Abstract;
The protective effects of hydroxytyrosol against UVB-induced DNA damage in HaCaT cells.: W. Guo et al.; Phytother. Res. 24, 352 (2009), Abstract;
Metabolism of the olive oil phenols hydroxytyrosol, tyrosol, and hydroxytyrosyl acetate by human hepatoma HepG2 cells.: R. Mateos et al.; J. Agric. Food. Chem. 53, 9897 (2005), Abstract;

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