Antioxidant comparable to resveratrol (Prod. No. BML-FR104). Is converted to hydroxytyrosol through hydrolysis by esterases. Reaches full oxygen radical absorbance capacity (ORAC) when converted to free hydoxytyrosol. ORAC values of hydroxytyrosol are about 50% higher than resveratrol, 10-fold higher than L(+)-ascorbic acid and 4-fold higher than (-)-epicatechin. Has been shown to have anticancer and antiviral effects.
Antibacterial at 400µg/mL against Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae.
Product Details
| Alternative Name: | HTS, 2-(3,4-Dihydroxyphenyl)-ethyl acetate |
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| Formula: | C10H12O4 |
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| MW: | 196.2 |
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| Source: | Synthetic |
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| CAS: | 69039-02-7 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Freely soluble in organic solvents; slightly soluble in water (10mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Scientific Background: | Hydroxytyrosol-acetate is a small-molecule phenolic compound found in the leaves and fruits of olive (Olea eurolaea). It is a metabolite of oleuropein (Ole), one of the major polyphenolic components of olive products. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells: M. Notarnicola, et al.; Genes Nutr.
6, 63 (2011),
Abstract;
Full Text
Synergistic antibacterial effects of polyphenolic compounds from olive mill wastewater: A. Tafesh, et al.; Evid. Based Complement. Alternat. Med.
2011, 431021 (2011),
Abstract;
Full Text
Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells.: J. Han et al.; Cytotechnology
59, 45 (2009),
Abstract;
Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1.: G. Corona et al.; JP. Mol. Nutr. Food Res.
53, 897 (2009),
Abstract;
Mechanism of the antiviral effect of hydroxytyrosol on influenza virus appears to involve morphological change of the virus.: K. Yamada et al.; Antiviral Res.
83, 35 (2009),
Abstract;
The protective effects of hydroxytyrosol against UVB-induced DNA damage in HaCaT cells.: W. Guo et al.; Phytother. Res.
24, 352 (2009),
Abstract;
Metabolism of the olive oil phenols hydroxytyrosol, tyrosol, and hydroxytyrosyl acetate by human hepatoma HepG2 cells.: R. Mateos et al.; J. Agric. Food. Chem.
53, 9897 (2005),
Abstract;
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