Fragment of a precursor to okadaic acid. Inactive against protein phosphatases in vitro. Potent toxin to whole cells, suggesting transport across the cell membrane and cleavage of the ester bond by cellular esterases.
Product Specification
| Formula: | C52H80O14 |
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| MW: | 929.2 |
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| Source: | Isolated from Prorocentrum lima. |
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| CAS: | 318536-96-8 |
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| Purity: | ≥90% |
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| Appearance: | Colorless solid. |
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| Solubility: | Soluble in methanol or DMSO. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Isolation and identification of a cis-C8-diol-ester of okadaic acid from Dinophysis acuta in New Zealand: C.O. Miles, et al.; Toxicon
48, 195 (2006),
Abstract;
Discovery of okadaic acid esters in the toxic dinoflagellate Dinophysis acuta from New Zealand using liquid chromatography/tandem mass spectrometry: T. Suzuki, et al.; Rapid Commun. Mass Spectrom.
18, 1131 (2004),
Abstract;
Comparative toxicity of the diarrhetic shellfish poisons, okadaic acid, okadaic acid diol-ester and dinophysistoxin-4, to the diatom Thalassiosira weissflogii: A.J. Windust, et al.; Toxicon
35, 1591 (1997),
Abstract;
Biosynthesis of DTX-4: Confirmation of a Polyketide Pathway, Proof of a Baeyer−Villiger Oxidation Step, and Evidence for an Unusual Carbon Deletion Process: J.L.C. Wright, et al.; JACS
118, 8757 (1996),
Abstract;
New diol esters isolated from cultures of the dinoflagellates Prorocentrum lima and Prorocentrum concavum: T. Hu, et al.; J. Nat. Prod.
55, 1631 (1992),
Abstract;
