Broad spectrum antifungal compound. Active against Candida, Acremonium, Cryptococcus neoformans, Trichosporon, Aspergillus, Fusarium sambucium (minimal inhibition concentration (MIC) range: 4-16μg/ml). Moderate activity against cancerous cells (Jurkat ATCC-TIB-152, L 929). No activity against bacteria (Bacillus subtilis, Streptomyces versicolor, Escherichia coli).
Product Specification
| Formula: | C62H99N11O24 |
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| MW: | 1381.7 |
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| Source: | Isolated from Hassallia sp. |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in 100% ethanol, methanol or DMSO; insoluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathway. : J. Vestola, et al.; PNAS
6, 111 (2014),
Abstract;
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Genome-derived insights into the biology of the hepatotoxic bloom-forming cyanobacterium Anabaena sp. strain 90: H. Wang, et al.; BMC Genomics
13, 613 (2012),
Abstract;
Full Text
Identification and toxigenic potential of a Nostoc sp.: B. Nowruzi, et al.; Algae
27, 303 (2012),
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Comparison of susceptibility and transcription profile of the new antifungal hassallidin A with caspofungin: T. Neuhof, et al.; BBRC
349, 740 (2006),
Abstract;
Hassallidin B--second antifungal member of the Hassallidin family: T. Neuhof, et al.; Bioorg. Med. Chem. Lett.
16, 4220 (2006),
Abstract;
Hassallidin A, a glycosylated lipopeptide with antifungal activity from the cyanobacterium Hassallia sp: T. Neuhof, et al.; J. Nat. Prod.
68, 695 (2005),
Abstract;
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