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Smoothened inhibitor
ALX-350-378-M001 1 mg 136.00 USD
ALX-350-378-M005 5 mg 496.00 USD
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Replaces Prod. #: BML-GR337

Cell permeable steroidal alkaloid. Structurally similar to cyclopamine (Prod. No. BML-GR334). Inhibits the sonic hedgehog (shh) pathway by interacting with smoothened. Can be used to induce abnormal morphogenesis in a number of experimental models. Tomatidine (Prod. No. BML-GR335) is a useful negative control.

Product Details

Alternative Name:(3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, 11-Ketocyclopamine
MI:14: 5264
Purity:≥98% (TLC)
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (5mg/ml), 100% ethanol (10mg/ml) or dimethyl formamide (6mg/ml). Slight warming may be required.
Shipping:Blue Ice
Long Term Storage:-20°C
Use/Stability:Stock solutions are stable for up to 3 months when stored at -20°C.
Handling:After reconstitution, prepare aliquots and store at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis: M.K. Cooper, et al.; Nat. Genet. 33, 508 (2003), Abstract;
Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium: C.M. Mistretta, et al.; Dev. Biol. 254, 1 (2003), Abstract;
Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions: J.A. Williams, et al.; PNAS 100, 4616 (2003), Abstract; Full Text
Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002), Abstract;
Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis: D. ten Berge, et al.; Development 128, 2929 (2001), Abstract; Full Text
Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport: J.P. Incardona, et al.; Dev. Biol. 224, 440 (2000), Abstract;
Teratogen-mediated inhibition of target tissue response to Shh signaling: M.K. Cooper, et al.; Science 280, 1603 (1998), Abstract;

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Blocks Hedgehog signaling
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Tomatidine . HCl 

Negative control for Cyclopamine
6192-62-7, Tomato leaves, ≥90% (TLC) | Print as PDF
BML-GR335-0025 25 mg 74.00 USD
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