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Cytochrome P450 activator
ALX-350-370-M500 500 mg 79.00 USD
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Dimer of indole-3-carbinol (Prod. No. ALX-350-347). Anticancer and antineoplastic agent. Induces apoptosis in human cancer cells. Activator of cytochrome P450. Partial agonist of aryl hydrocarbon receptor (AhR).

Product Details

Alternative Name:DIM
Purity:≥98% (HPLC)
Appearance:White to light pink powder.
Solubility:Soluble in DMSO (200mg/ml); insoluble in water.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

3,3’-diindolylmethane reduces levels of HIF-1alpha and HIF-1 activity in hypoxic cultured human cancer cells: J.E. Riby, et al.; Biochem. Pharmacol. 75, 1858 (2008), Abstract;
3,3’-Diindolylmethane stimulates murine immune function in vitro and in vivo: L. Xue, et al.; J. Nutr. Biochem. 19, 336 (2008), Abstract;
Indole-3-carbinol as a chemopreventive and anti-cancer agent: J.R. Weng, et al.; Cancer Lett. 262, 153 (2008), Abstract;
Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines: L. Mulvey, et al.; Mol. Med. 13, 69 (2007), Abstract; Full Text
Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor: E.V. Hestermann & M. Brown; Mol. Cell. Biol. 23, 7920 (2003), Abstract; Full Text
3,3’-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices: B.G. Lake, et al.; Xenobiotica 28, 803 (1998), Abstract;
3,3’-Diindolylmethane induces apoptosis in human cancer cells: X. Ge, et al.; BBRC 228, 153 (1996), Abstract;
Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells: I. Chen, et al.; Biochem. Pharmacol. 51, 1069 (1996), Abstract;
The anticarcinogen 3,3'-diindolylmethane is an inhibitor of cytochrome P-450: D.M. Stresser, et al.; J. Biochem. Toxicol. 10, 191 (1995), Abstract;
Oligomerization of indole-3-carbinol in aqueous acid: K.R. Grose & L.F. Bjeldanes; Chem. Res. Toxicol. 5, 188 (1992), Abstract;