Dimer of indole-3-carbinol (Prod. No. ALX-350-347). Anticancer and antineoplastic agent. Induces apoptosis in human cancer cells. Activator of cytochrome P450. Partial agonist of aryl hydrocarbon receptor (AhR).
Product Details
| Alternative Name: | DIM |
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| Formula: | C17H14N2 |
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| MW: | 246.3 |
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| CAS: | 1968-05-4 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to light pink powder. |
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| Solubility: | Soluble in DMSO (200mg/ml); insoluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
3,3’-diindolylmethane reduces levels of HIF-1alpha and HIF-1 activity in hypoxic cultured human cancer cells: J.E. Riby, et al.; Biochem. Pharmacol.
75, 1858 (2008),
Abstract;
3,3’-Diindolylmethane stimulates murine immune function in vitro and in vivo: L. Xue, et al.; J. Nutr. Biochem.
19, 336 (2008),
Abstract;
Indole-3-carbinol as a chemopreventive and anti-cancer agent: J.R. Weng, et al.; Cancer Lett.
262, 153 (2008),
Abstract;
Interplay of genes regulated by estrogen and diindolylmethane in breast cancer cell lines: L. Mulvey, et al.; Mol. Med.
13, 69 (2007),
Abstract;
Full Text
Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor: E.V. Hestermann & M. Brown; Mol. Cell. Biol.
23, 7920 (2003),
Abstract;
Full Text
3,3’-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices: B.G. Lake, et al.; Xenobiotica
28, 803 (1998),
Abstract;
3,3’-Diindolylmethane induces apoptosis in human cancer cells: X. Ge, et al.; BBRC
228, 153 (1996),
Abstract;
Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells: I. Chen, et al.; Biochem. Pharmacol.
51, 1069 (1996),
Abstract;
The anticarcinogen 3,3'-diindolylmethane is an inhibitor of cytochrome P-450: D.M. Stresser, et al.; J. Biochem. Toxicol.
10, 191 (1995),
Abstract;
Oligomerization of indole-3-carbinol in aqueous acid: K.R. Grose & L.F. Bjeldanes; Chem. Res. Toxicol.
5, 188 (1992),
Abstract;
