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Cinnamtannin B-1

Potent antioxidant
ALX-350-365-M005 5 mg 276.00 USD
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A-type proanthocyanidin contained in several plant species such as Laurus nobilis L. , Vaccinium vitis-idaea, Parameria laevigata, Cinnamomum zeylanicum, Lindera umbellata, Metaxya rostrata. Potent antioxidant, TEAC method (nM Trolox) = 0.95. Protective agent against oxidative stress and apoptosis in human platelets.
Inhibitory activity against cyclooxygenase-2 (COX-2) in vitro.
DPPH radical scavenging IC50 6.14µM
Lipid peroxidation inhibition 159.74
Nitric oxide inhibition 10.28
Antibacterial against B.subtilis (9mm, 20mg/ml)

Product Specification

Alternative Name:Epicatechin-(4β→8,2β→O→7)-epicatechin-(4α→8)-epicatechin
Source:Isolated from Laurus nobilis L.
Purity:≥95% (HPLC)
Identity:Determined by 1H-NMR.
Appearance:Brown solid.
Solubility:Soluble in 100% ethanol, methanol or in a mixture of DMSO and water.
Long Term Storage:-20°C
Handling:Protect from light. Keep under inert gas.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Bioactive A-Type Proanthocyanidins from Cinnamomum cassia: K.B. Killday, et al.; J. Nat. Prod. 74, 1833 (2011), Abstract;
Ethanol reduces kainate-evoked glutamate secretion in rat hippocampal astrocytes: P. Santofimia-Castano, et al.; Brain Res. 1402, 1 (2011), Abstract;
Doubly linked, A-type proanthocyanidin trimer and other constituents of Ixora coccinea leaves and their antioxidant and antibacterial properties : T.O. Idowu, et al.; Phytochemistry 71, 2092 (2010), Abstract;
Effect of cinnamtannin B-1 on CCK-8-evoked responses in mouse pancreatic acinar cells: R. Rivera-Barreno, et al.; Clin. Exp. Pharmacol. Physiol. 37, 980 (2010), Abstract;
Increased calcium influx in the presence of ethanol in mouse pancreatic acinar cells: A. Del Castillo-Vaquero, et al.; Int. J. Exp. Pathol. 91, 114 (2010), Abstract;
Ethanol exerts dual effects on calcium homeostasis in CCK-8-stimulated mouse pancreatic acinar cells: M. Fernandez-Sanchez, et al.; BMC Cell Biol. 10, 77 (2009), Abstract;
Phytochemical Composition and Antioxidant Activity of Laurus nobilis L. Leaf Infusion: S. Dall'Acqua, et al.; J. Med. Food 12, 869 (2009), Abstract;
Chemical and Pharmacological Investigations of Metaxya rostrata: J. Wirtbauer, et al.; Z. Naturforsch. 63, 465 (2008), Abstract;
Cinnamtannin B-1 as an antioxidant and platelet aggregation inhibitor: J.J. López, et al.; Life Sciences 82, 977 (2008), Abstract;
Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets: N. Ben Amor, et al.; J. Med. Chem. 50, 3937 (2007), Abstract;
Cinnamtannin B-1 from bay wood exhibits antiapoptotic effects in human platelets: A. Bouaziz, et al.; Apoptosis 12, 489 (2007), Abstract;
Cinnamtannin B-1 from bay wood reduces abnormal intracellular Ca2+ homeostasis and platelet hyperaggregability in type 2 diabetes mellitus patients: A. Bouaziz, et al.; Arch. Biochem. Biophys. 457, 235 (2007), Abstract;
Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity: G.K. Jayaprakasha, et al.; J. Agric. Food Chem. 54, 1672 (2006), Abstract;
Cinnamtannin B1 activity on adipocytes formation: M. Taher, et al.; Med. J. Malaysia 59, 97 (2004), Abstract;
Studies on the constituents of bark of Parameria laevigata Moldenke: K. Kamiya, et al.; Chem. Pharm. Bull. 49, 551 (2001), Abstract; Full Text
Antioxidant activity of tannin components from Vaccinium vitis-idaea L: K.Y. Ho, et al.; J. Pharm. Pharmacol. 51, 1075 (1999), Abstract;
Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents: Y. Kashiwada, et al.; J. Nat. Prod. 55, 1033 (1992), Abstract;
Pharmacological Studies on Linderae umbellatae Ramus, IV*. Effects of condensed tannin related compounds on peptic activity and stress-induced gastric lesions in mice: N. Ezaki, et al.; Planta Med. 51, 34 (1985), Abstract;

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