Shows antiviral, antibacterial, antifungal and insecticidal properties. Binds DNA through single and double-stranded cross-linking after photoactivation. Used as photochemical probe in studies of DNA mutation and repair mechanisms. Causes photosensitization in human.
Product Details
| Alternative Name: | Ficusin, 7H-Furo[3,2-g]benzopyran-7-one |
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| Formula: | C11H6O3 |
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| MW: | 186.2 |
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| Source: | Isolated from Psoralea corylifolia. |
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| CAS: | 66-97-7 |
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| MI: | 14: 7928 |
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| RTECS: | LV0944000 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in ethyl acetate or acetone; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
CYP3A4 inhibition by Psoralea corylifolia and its major components in human recombinant enzyme, differentiated human hepatoma HuH-7 and HepaRG cells: Y. Liu & T.J. Flynn; Toxicol. Rep.
2, 530 (2015),
Application(s): Cell Culture ,
Abstract;
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Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells: S. Couve-Privat, et al.; Nucl. Acids Res.
35, 5672 (2007),
Abstract;
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Site-directed gene mutation at mixed sequence targets by psoralen-conjugated pseudo-complementary peptide nucleic acids: K.H. Kim, et al.; Nucl. Acids Res.
35, 7604 (2007),
Abstract;
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Psoralen photocrosslinking, a tool to study the chromatin structure of RNA polymerase I--transcribed ribosomal genes: M. Toussaint, et al.; Biochem. Cell Biol.
83, 449 (2005),
Abstract;
DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria: C. Cullinane & V.A. Bohr; Cancer Res.
58, 1400 (1998),
Abstract;
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Probing DNA structure with psoralen in vitro: D.W. Ussery, et al.; Meth. Enzymol.
212, 242 (1992),
Abstract;
Electron microscopic identification of supercoiled regions in complex DNA structures: R.B. Inman & M. Schnos; J. Mol. Biol.
193, 377 (1987),
Abstract;
Psoralens as photoactive probes of nucleic acid structure and function: organic chemistry, photochemistry, and biochemistry: G.D. Cimino, et al.; Annu. Rev. Biochem.
54, 1151 (1985), (Review),
Abstract;
Psoralen phototoxicity: correlation with serum and epidermal 8-methoxypsoralen and 5-methoxypsoralen in the guinea pig: A. Kornhauser, et al.; Science
217, 733 (1982),
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