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iNOS inhibitor
ALX-350-350-M005 5 mg 55.00 USD
ALX-350-350-M025 25 mg 254.00 USD
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Potent and highly tolerable antitumor and antiangiogenic compound. Anxiolytic, anti-thrombotic and antibacterial. Shows central depressant effects in vivo. Inhibitor of nitric oxide (NO) and TNF-α production in LPS-activated macrophages by the suppression of inducible nitric oxide synthase (iNOS; NOS II) expression (IC50=6.4µM). Isomeric with magnolol (Prod. No. ALX-350-352). Inhibits NF-κB activation. Potent scavenger of superoxide and peroxyl radicals.

Product Details

Alternative Name:5,3’-Diallyl-2,4’-biphenyldiol, 5,3’-Diallyl-2,4’-dihydroxydiphenyl
Source:Isolated from Magnolia officinalis.
MI:14: 4742
Purity:≥98% (HPLC)
Appearance:White to off-white powder.
Solubility:Soluble in DMSO, 100% ethanol or methanol.
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression: B.H. Kim & J.Y. Cho; Acta Pharmacol. Sin. 29, 113 (2008), Abstract;
Honokiol is a potent scavenger of superoxide and peroxyl radicals: S. Dikalov, et al.; Biochem. Pharmacol. 76, 589 (2008), Abstract;
Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors: S.J. Han, et al.; Biol. Pharm. Bull. 30, 2201 (2007), Abstract; Full Text
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway: K.S. Ahn, et al.; Mol. Cancer Res. 4, 621 (2006), Abstract; Full Text
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo: X. Bai, et al.; J. Biol. Chem. 278, 35501 (2003), Abstract; Full Text
Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells: S.E. Yang, et al.; Biochem. Pharmacol. 63, 1641 (2002), Abstract;
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages: H.J. Son, et al.; Planta Med. 66, 469 (2000), Abstract;
Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine: Y. Maruyama, et al.; J. Nat. Prod. 61, 135 (1998), Abstract;
Pharmacological properties of Magnolol and Honokiol extracted from Magnolia officinalis: Central depressant effects: K. Watanabe, et al.; Planta Med. 49, 103 (1983), Abstract;

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ALX-350-352-M005 5 mg 64.00 USD
ALX-350-352-M025 25 mg 339.00 USD
Do you need bulk/larger quantities?

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