Fungal metabolite. Glucose-6-phosphatase inhibitor. Potent inhibitor of phospholipase C. Inhibits telomerase, viral reverse transcriptase, peptidoglycan formation and prostaglandin biosynthesis.
Product Details
| Formula: | C31H34O10 |
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| MW: | 566.6 |
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| Source: | Isolated from an unidentified fungus MST-FP1888. |
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| CAS: | 71950-67-9 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Thielavins as glucose-6-phosphatase (G6Pase) inhibitors: producing strain, fermentation, isolation, structural elucidation and biological activitie: S. Sakemi, et al.; J. Antibiot. (Tokyo)
55, 941 (2002),
Abstract;
Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B: K. Togashi, et al.; Biosci. Biotechnol. Biochem.
65, 651 (2001),
Abstract;
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Screening systems for detecting inhibitors of cell wall transglycosylation in Enterococcus. Cell wall transglycosylation inhibitors in Enterococcus: N. Mani, et al.; J. Antibiot. (Tokyo)
51, 471 (1998),
Abstract;
The structures of thielavins A, B and C. Prostaglandin synthetase inhibitors from fungi: N. Kitahara, et al.; J. Antibiot. (Tokyo)
36, 599 (1983),
Abstract;
Thielavin A and B, new inhibitors of prostaglandin biosynthesis produced by Thielavia terricola: N. Kitahara, et al.; J. Antibiot. (Tokyo)
34, 1562 (1981),
Abstract;
