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TRPV1 antagonist
ALX-350-330-M050 50 mg 43.00 USD
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Replaces Prod. #: BML-CA233

A cell permeable, non-pungent TRPV1 antagonist (Ki=5.95µM in rat) that induces apoptosis in U937 cells. Inhibits nitric oxide (NO) production. Also inhibits tumor cell migration in vitro. Is effective against multidrug-resistant cancer cells. Inhibits angiogenesis.

Product Details

Alternative Name:8,13,13b,14-Tetrahydro-14-methylindolo[2’3’-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one
Source:Synthetic. Originally isolated from Evodia rutaecarpa.
MI:14: 3908
Purity:≥98% (HPLC)
Appearance:Off-white to light yellow solid.
Solubility:Soluble in DMSO (5mg/ml; warm to 40°C).
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Caspase-dependent and caspase-independent apoptosis induced by evodiamine in human leukemic U937 cells: T.J. Lee, et al.; Mol. Cancer Ther. 5, 2398 (2006), Abstract;
Evodiamine inhibits in vitro angiogenesis: Implication for antitumorgenicity: K.G. Shyu et al.; Life. Sci. 78, 2234 (2006), Abstract;
Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo: C.H. Liao, et al.; Carcinogenesis 26, 968 (2005), Abstract;
Evodiamine functions as an agonist for the vanilloid receptor TRPV1: L.V. Pearce et al.; Org. Biomol. Chem. 2, 2281 (2004), Abstract;
Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis: Y. Zhang, et al.; Acta Pharmacol. Sin. 25, 83 (2004), Abstract;
Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells: X.F. Fei, et al.; Cancer Sci. 94, 92 (2003), Abstract;
Inhibitory effects of evodiamine on in vitro invasion and experimental lung metastasis of murine colon cancer cells: M. Ogasawara, et al.; Biol. Pharm. Bull. 24, 917 (2001), Abstract;
Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages: W.F. Chiou, et al.; J. Nat. Prod. 60, 708 (1997), Abstract;
Isolation of evodiamine, a powerful cardiotonic principle, from Evodia rutaecarpa Bentham (Rutaceae): N. Shoji, et al.; J. Pharm. Sci. 75, 612 (1986), Abstract;

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