Replaces Prod. #: BML-CA233
A cell permeable, non-pungent TRPV1 antagonist (Ki=5.95µM in rat) that induces apoptosis in U937 cells. Inhibits nitric oxide (NO) production. Also inhibits tumor cell migration in vitro. Is effective against multidrug-resistant cancer cells. Inhibits angiogenesis.
Product Details
| Alternative Name: | 8,13,13b,14-Tetrahydro-14-methylindolo[2’3’-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one |
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| Formula: | C19H17N3O |
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| MW: | 303.4 |
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| Source: | Synthetic. Originally isolated from Evodia rutaecarpa. |
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| CAS: | 518-17-2 |
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| MI: | 14: 3908 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Off-white to light yellow solid. |
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| Solubility: | Soluble in DMSO (5mg/ml; warm to 40°C). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Caspase-dependent and caspase-independent apoptosis induced by evodiamine in human leukemic U937 cells: T.J. Lee, et al.; Mol. Cancer Ther.
5, 2398 (2006),
Abstract;
Evodiamine inhibits in vitro angiogenesis: Implication for antitumorgenicity: K.G. Shyu et al.; Life. Sci.
78, 2234 (2006),
Abstract;
Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo: C.H. Liao, et al.; Carcinogenesis
26, 968 (2005),
Abstract;
Evodiamine functions as an agonist for the vanilloid receptor TRPV1: L.V. Pearce et al.; Org. Biomol. Chem.
2, 2281 (2004),
Abstract;
Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis: Y. Zhang, et al.; Acta Pharmacol. Sin.
25, 83 (2004),
Abstract;
Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells: X.F. Fei, et al.; Cancer Sci.
94, 92 (2003),
Abstract;
Inhibitory effects of evodiamine on in vitro invasion and experimental lung metastasis of murine colon cancer cells: M. Ogasawara, et al.; Biol. Pharm. Bull.
24, 917 (2001),
Abstract;
Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages: W.F. Chiou, et al.; J. Nat. Prod.
60, 708 (1997),
Abstract;
Isolation of evodiamine, a powerful cardiotonic principle, from Evodia rutaecarpa Bentham (Rutaceae): N. Shoji, et al.; J. Pharm. Sci.
75, 612 (1986),
Abstract;
