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Evodiamine

TRPV1 antagonist



ALX-350-330-M050	50 mg	48.00 USD
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Replaces Prod. #: BML-CA233

A cell permeable, non-pungent TRPV1 antagonist (K_i=5.95µM in rat) that induces apoptosis in U937 cells. Inhibits nitric oxide (NO) production. Also inhibits tumor cell migration in vitro. Is effective against multidrug-resistant cancer cells. Inhibits angiogenesis.

Product Details

Alternative Name:	8,13,13b,14-Tetrahydro-14-methylindolo[2’3’-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one

Formula:	C₁₉H₁₇N₃O

MW:	303.4

Source:	Synthetic. Originally isolated from Evodia rutaecarpa.

CAS:	518-17-2

MI:	14: 3908

Purity:	≥98% (HPLC)

Appearance:	Off-white to light yellow solid.

Solubility:	Soluble in DMSO (5mg/ml; warm to 40°C).

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Handling:	Protect from light.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Caspase-dependent and caspase-independent apoptosis induced by evodiamine in human leukemic U937 cells: T.J. Lee, et al.; Mol. Cancer Ther. 5, 2398 (2006), Abstract;

Evodiamine inhibits in vitro angiogenesis: Implication for antitumorgenicity: K.G. Shyu et al.; Life. Sci. 78, 2234 (2006), Abstract;

Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo: C.H. Liao, et al.; Carcinogenesis 26, 968 (2005), Abstract;

Evodiamine functions as an agonist for the vanilloid receptor TRPV1: L.V. Pearce et al.; Org. Biomol. Chem. 2, 2281 (2004), Abstract;

Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis: Y. Zhang, et al.; Acta Pharmacol. Sin. 25, 83 (2004), Abstract;

Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells: X.F. Fei, et al.; Cancer Sci. 94, 92 (2003), Abstract;

Inhibitory effects of evodiamine on in vitro invasion and experimental lung metastasis of murine colon cancer cells: M. Ogasawara, et al.; Biol. Pharm. Bull. 24, 917 (2001), Abstract;

Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages: W.F. Chiou, et al.; J. Nat. Prod. 60, 708 (1997), Abstract;

Isolation of evodiamine, a powerful cardiotonic principle, from Evodia rutaecarpa Bentham (Rutaceae): N. Shoji, et al.; J. Pharm. Sci. 75, 612 (1986), Abstract;