Potent inhibitor of cytokine-induced activation of STAT1α leading to the inhibition of inducible expression of proinflammatory enzymes (COX-2, iNOS (NOS II)) and cytokines (TNF-α).
Product Details
| Formula: | C28H34O5 |
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| MW: | 450.6 |
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| Source: | Isolated from Penicillium sp. |
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| Purity: | ≥95% (HPLC) |
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| Identity: | Determined by MS. |
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| Appearance: | Yellow powder. |
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| Solubility: | Soluble in methanol. |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The Priming Potential of Interferon Lambda-1 for Antiviral Defense in the Oral Mucosa: Y. Shikama, et al.; Inflammation (2022),
Abstract;
Immune Regulation of Interleukin-27 in Malignant Pleural Effusion: S. Li, et al.; Chin. Med. J. (Engl)
128, 1932 (2015),
Abstract;
Full Text
S14-95, a novel inhibitor of the JAK/STAT pathway from a Penicillium species: G. Erkel, et al.; J. Antibiot.
56, 337 (2003),
Abstract;
Full Text
Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi: Y. Yao, et al.; Mol. Pharmacol.
63, 383 (2003),
Abstract;
Full Text
General Literature References
Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases: T. Itoh, et al.; Nat. Chem.
2, 858 (2010),
Abstract;
