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STAT1α inhibitor
ALX-350-299-MC05 0.5 mg 336.00 USD
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Potent inhibitor of cytokine-induced activation of STAT1α leading to the inhibition of inducible expression of proinflammatory enzymes (COX-2, iNOS (NOS II)) and cytokines (TNF-α).

Product Details

Source:Isolated from Penicillium sp.
Purity:≥95% (HPLC)
Identity:Determined by MS.
Appearance:Yellow powder.
Solubility:Soluble in methanol.
Shipping:Ambient Temperature
Short Term Storage:+4°C
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

The Priming Potential of Interferon Lambda-1 for Antiviral Defense in the Oral Mucosa: Y. Shikama, et al.; Inflammation 45, 1348 (2022), Abstract;
Immune Regulation of Interleukin-27 in Malignant Pleural Effusion: S. Li, et al.; Chin. Med. J. (Engl) 128, 1932 (2015), Abstract; Full Text
S14-95, a novel inhibitor of the JAK/STAT pathway from a Penicillium species: G. Erkel, et al.; J. Antibiot. 56, 337 (2003), Abstract; Full Text
Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi: Y. Yao, et al.; Mol. Pharmacol. 63, 383 (2003), Abstract; Full Text

General Literature References

Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases: T. Itoh, et al.; Nat. Chem. 2, 858 (2010), Abstract;