β-Carboline alkaloid with anti-inflammatory, antimalarial, antifungal, anti-HIV-1 and insecticidal activity. Also active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. Inhibits GSK-3. Has native fluorescence, highest when solubilized in methanol (Ex: 340nm, Em: 387nm).
Product Details
| Formula: | C36H44N4O |
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| MW: | 548.8 |
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| Source: | Isolated from Xestospongia sp. |
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| CAS: | 104196-68-1 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Off white to yellow solid. |
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| Solubility: | Soluble in DMSO, methanol or 100% ethanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease: M. Hamann, et al.; J. Nat. Prod.
70, 1397 (2007),
Abstract;
Antimalarial activity of a new family of analogues of manzamine A: J.D. Winkler, et al.; Org. Lett.
8, 2591 (2006),
Abstract;
New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases: M. Yousaf, et al.; J. Med. Chem.
47, 3512 (2004),
Abstract;
New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge: K.V. Rao, et al.; J. Nat. Prod.
66, 823 (2003),
Abstract;
Spectrofluorimetric determination of manzamine A in spiked human urine and plasma: A. Khalil, et al.; Pharmazie
58, 385 (2003),
Abstract;
Immune-mediated parasite clearance in mice infected with Plasmodium berghei following treatment with manzamine A: K.K. Ang, et al.; Parasitol. Res.
87, 715 (2001),
Abstract;
In vivo antimalarial activity of the beta-carboline alkaloid manzamine A: K.K. Ang, et al.; Antimicrob. Agents Chemother.
44, 1645 (2000),
Abstract;
Full Text
Four new bioactive manzamine-type alkaloids from the Philippine marine sponge Xestospongia ashmorica: R.A. Edrada, et al.; J. Nat. Prod.
59, 1056 (1996),
Abstract;
