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Manzamine A

GSK-3 inhibitor
 
ALX-350-294-M001 1 mg 246.00 USD
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β-Carboline alkaloid with anti-inflammatory, antimalarial, antifungal, anti-HIV-1 and insecticidal activity. Also active against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. Inhibits GSK-3. Has native fluorescence, highest when solubilized in methanol (Ex: 340nm, Em: 387nm).

Product Specification

Formula:C36H44N4O
 
MW:548.8
 
Source:Isolated from Xestospongia sp.
 
CAS:104196-68-1
 
Purity:≥98% (HPLC)
 
Appearance:Off white to yellow solid.
 
Solubility:Soluble in DMSO, methanol or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Regulatory Status:RUO - Research Use Only
 
350-294
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350-294

Product Literature References

Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease: M. Hamann, et al.; J. Nat. Prod. 70, 1397 (2007), Abstract;
Antimalarial activity of a new family of analogues of manzamine A: J.D. Winkler, et al.; Org. Lett. 8, 2591 (2006), Abstract;
New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases: M. Yousaf, et al.; J. Med. Chem. 47, 3512 (2004), Abstract;
New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge: K.V. Rao, et al.; J. Nat. Prod. 66, 823 (2003), Abstract;
Spectrofluorimetric determination of manzamine A in spiked human urine and plasma: A. Khalil, et al.; Pharmazie 58, 385 (2003), Abstract;
Immune-mediated parasite clearance in mice infected with Plasmodium berghei following treatment with manzamine A: K.K. Ang, et al.; Parasitol. Res. 87, 715 (2001), Abstract;
In vivo antimalarial activity of the beta-carboline alkaloid manzamine A: K.K. Ang, et al.; Antimicrob. Agents Chemother. 44, 1645 (2000), Abstract; Full Text
Four new bioactive manzamine-type alkaloids from the Philippine marine sponge Xestospongia ashmorica: R.A. Edrada, et al.; J. Nat. Prod. 59, 1056 (1996), Abstract;

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