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Chk inhibitor
ALX-350-290-C100 100 µg 130.00 USD
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Inhibitor of G2 DNA damage checkpoint (IC50=8µM) and check point kinases 1 (Chk1) (IC50=3µM) and 2 (Chk2) (IC50=3.5µM). Unlike other checkpoint inhibitors DBH does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related protein. Also inhibits MAP kinase kinase 1 (MEK-1) (IC50=881nM) but is not as potent as 10Z-hymenialdisine (IC50=6nM).

Product Details

Alternative Name:DBH, 4-(2-Amino-4-oxo-2-imidazolin-5-ylidene)-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one
Source:Isolated from sponge Axinella carteri.
Purity:≥95% (HPLC)
Identity:Determined by 1H-NMR and MS.
Appearance:Yellow solid.
Solubility:Soluble in 100% ethanol or DMSO.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light. Keep under inert gas.
Regulatory Status:RUO - Research Use Only
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Product Literature References

G2 checkpoint abrogators as anticancer drugs: T. Kawabe; Mol. Cancer Ther. 3, 513 (2004), Abstract;
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1): D. Tasdemir, et al.; J. Med. Chem. 45, 529 (2002), Abstract;
Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine: D. Curman, et al.; J. Biol. Chem. 276, 17914 (2001), Abstract; Full Text