Racemic mixture of (+/-)-Isoxanthohumol.
Prenylated flavonoid. Phytoestrogen. Induces apoptosis in mature adipocytes.
Product Details
Alternative Name: | (±)-Isoxanthohumol |
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Formula: | C21H22O5 |
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MW: | 354.4 |
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Source: | Synthetic. |
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CAS: | 521-48-2 |
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Purity: | ≥98% (1H-NMR) |
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Identity: | Determined by 1H-NMR, 13C-NMR and LC-MS. |
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Appearance: | Off-white to yellow powder. |
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Solubility: | Soluble in DMSO (50mg/ml) or methanol (50mg/ml). |
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Shipping: | Ambient Temperature |
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Long Term Storage: | +4°C |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibition of TGF-beta signaling, vasculogenic mimicry and proinflammatory gene expression by isoxanthohumol: A. Serwe, et al.; Invest. New Drugs
30, 898 (2012),
Abstract;
Inhibitors of hyaluronan export from hops prevent osteoarthritic reactions: D. Stracke, et al.; Mol. Nutr. Food Res.
55, 485 (2010),
Abstract;
Endocrine Disrupting Compounds (EDCs): Disrupting Human Endocrine Physiology and the Intricate Reproductive Balance: S.A. Sidiropoulos; UTMJ
85, 76 (2008),
Abstract;
The Impact of a Xanthohumol-Enriched Hop Product on the Behavior of Xanthohumol and Isoxanthohumol in Pale and Dark Beers:
A Pilot Scale Approach: P.J. Magalhaes, et al.; J. Inst. Brew.
114, 246 (2008),
Full Text
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis: J.Y. Yang, et al.; Apoptosis
12, 1953 (2007),
Abstract;
Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.): J. Guo, et al.; Drug Metab. Dispos.
34, 1152 (2006),
Abstract;
The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine: S. Possemiers, et al.; J. Nutr.
136, 1862 (2006),
Abstract;
Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes: D. Nikolic, et al.; J. Mass Spectrom.
40, 289 (2005),
Abstract;
Inhibition of endothelial cell functions by novel potential cancer chemopreventive agents: E. Bertl, et al.; BBRC
325, 287 (2004),
Abstract;
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry
65, 1317 (2004), (Review),
Abstract;