Cell permeable F-actin probe. Induces actin polymerization. Completely inhibits the binding of phalloidin to F-actin. Antifungal and anti-proliferative agent.
Product Details
| Alternative Name: | Jaspamide |
| |
| Formula: | C36H45BrN4O6 |
| |
| MW: | 709.7 |
| |
| Source: | Isolated from Jaspis splendens. |
| |
| CAS: | 102396-24-7 |
| |
| Purity: | ≥97% (HPLC) |
| |
| Identity: | Determined by 1H-NMR and ESI-MS. |
| |
| Appearance: | Off-white to yellow solid. |
| |
| Solubility: | Soluble in 100% ethanol, 83% methanol or DMSO. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Handling: | Protect from light. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Genetic Suppression of Defective Profilin by Attenuated Myosin II Reveals a Potential Role for Myosin II in Actin Dynamics in vivo in fission yeast: P. Zambon, et al.; Mol. Biol. Cell
31, 2107 (2020),
Abstract;
Full Text
Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo: T. Chimura, et al.; PLoS One
10, e0125119 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Different contributions of clathrin-and caveolae-mediated endocytosis of vascular endothelial cadherin to lipopolysaccharide-induced vascular : Y. Zhang, et al.; PLoS One
9, e106328 (2014),
Abstract;
Full Text
Mitochondria localize to the cleavage furrow in mammalian cytokinesis: E.J. Lawrence, et al.; PLoS One
8, e72886 (2013),
Abstract;
Full Text
Gliding motility of Babesia bovis merozoites visualized by time-lapse video microscopy: M. Asada, et al.; PLoS One
7, e35227 (2012),
Abstract;
Full Text
Actin dynamics counteract membrane tension during clathrin-mediated endocytosis: S. Boulant, et al.; Nat. Cell Biol.
13, 1124 (2011),
Abstract;
Dynamic macrophage "probing" is required for the efficient capture of phagocytic targets: R.S. Flannagan, et al.; J. Cell Biol.
191, 1205 (2010),
Abstract;
Full Text
Rab27a negatively regulates phagocytosis by prolongation of the actin-coating stage around phagosomes: K. Yokoyama, et al.; J. Biol. Chem.
286, 5375 (2010),
Abstract;
Dynamics of an F-actin aggresome generated by the actin-stabilizing toxin jasplakinolide: F. Lázaro-Diéguez, et al.; J. Cell Sci.
121, 1415 (2008),
Abstract;
A simple model for the cooperative stabilisation of actin filaments by phalloidin and jasplakinolide: B. Visegrády, et al.; FEBS Lett.
579, 6 (2005),
Abstract;
A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets. Evidence for conformational coupling: J.A. Rosado, et al.; J. Biol. Chem.
275, 7527 (2000),
Abstract;
Full Text
Effects of jasplakinolide on the kinetics of actin polymerization. An explanation for certain in vivo observations: M.R. Bubb, et al.;; J. Biol. Chem.
275, 5163 (2000),
Abstract;
Full Text
Actin stabilization by jasplakinolide enhances apoptosis induced by cytokine deprivation: S.C. Posey & B.E. Bierer; J. Biol. Chem.
274, 4259 (1999),
Abstract;
Full Text
Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide: L.P. Cramer; Curr. Biol.
9, 1095 (1999),
Abstract;
The anti-proliferative agent jasplakinolide rearranges the actin cytoskeleton of plant cells: H. Sawitzky, et al.; Eur. J. Cell Biol.
78, 424 (1999),
Abstract;
Jasplakinolide: interaction with radiation and hyperthermia in human prostate carcinoma and Lewis lung carcinoma: H. Takeuchi, et al.; Cancer Chemother. Pharmacol.
42, 491 (1998),
Abstract;
Growth modulation and differentiation of acute myeloid leukemia cells by jaspamide: I. Fabian, et al.; Exp. Hematol.
23, 583 (1995),
Abstract;
Jasplakinolide's inhibition of the growth of prostate carcinoma cells in vitro with disruption of the actin cytoskeleton: A.M. Senderowicz, et al.; J. Natl. Cancer Inst.
87, 46 (1995),
Abstract;
Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin: M.R. Bubb, et al.; J. Biol. Chem.
269, 14869 (1994),
Abstract;
Full Text
In vitro screening of crude extracts and pure metabolites obtained from marine invertebrates for the treatment of breast cancer: J. Stingl, et al.; Cancer Chemother. Pharmacol.
30, 401 (1992),
Abstract;
New class of antifungal agents: jasplakinolide, a cyclodepsipeptide from the marine sponge, Jaspis species: V.R. Scott, et al.; Antimicrob. Agents Chemother.
32, 1154 (1988),
Abstract;
