Specific CDK4 inhibitor (IC50=3.1µM) inducing growth inhibition of p16-altered tumors.
Product Details
| Alternative Name: | 3-Amino-9-thio(10H)-acridone |
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| Formula: | C13H10N2S |
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| MW: | 226.3 |
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| CAS: | 129821-08-5 |
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| Purity: | ≥95% |
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| Appearance: | White to reddish brown powder |
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| Solubility: | Soluble in DMSO or dimethyl formamide. |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Elevated Serum Antibody Levels against Cyclin L2 in Patients with Esophageal Squamous Cell Carcinomai : H. Shimada, et al.; J. Cancer Sci. Ther.
7, 60 (2015),
Application(s): Cell Culture,
Full Text
3-Amino thioacridone, a selective cyclin-dependent kinase 4 inhibitor, attenuates kainic acid-induced apoptosis in neurons: E. Verdaguer, et al.; Neuroscience
120, 599 (2003),
Abstract;
The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4: A. Kubo, et al.; Clin. Cancer Res.
5, 4279 (1999),
Abstract;
