Inhibits eukaryotic RNA-polymerase II with high efficiency, but not eukaryotic RNA-polymerase I, or bacterial or viral RNA-polymerases. Inhibits mammalian protein synthesis.
Product Specification
| Formula: | C39H54N10O14S |
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| MW: | 919.0 |
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| Source: | Isolated from Amanita phalloides mushrooms. |
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| CAS: | 23109-05-9 |
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| MI: | 14: 373 |
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| RTECS: | BD6195000 |
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| Purity: | ≥90% |
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| Appearance: | White to light yellow powder. |
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| Solubility: | Soluble in 100% ethanol (5mg/ml), DMSO, dimethyl formamide, methanol or water. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base. |
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| Handling: | Protect from light. |
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Product Literature References
Alpha-amanitin blocks translocation by human RNA polymerase II: X.Q. Gong, et al.; J. Biol. Chem.
279, 27422 (2004),
Abstract;
Fifty years of amanitin: T. Wieland & H. Faulstich; Experientia
47, 1189 (1991), (Review),
Abstract;
Specific inhibition of nuclear RNA polymerase II by alpha-amanitin: T.J. Lindell, et al.; Science
170, 447 (1970),
Abstract;
Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver: F. Stirpe & L. Fiume; Biochem. J.
103, 67P (1967),
Abstract;
