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Sceptrin . dihydrochloride

Acetylcholine receptor inhibitor
ALX-350-264-M001 1 mg 124.00 USD
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Inhibits the growth of several Gram-positive and Gram-negative bacteria. Competitively inhibits muscarinic acetylcholine receptors.

Product Details

Formula:C22H24Br2N10O2 . 2HCl
MW:620.3 . 72.9
Source:Isolated from the sponge Agelas nakamurai.
Purity:≥97% (HPLC)
Identity:Determined by 1H-NMR, 13C-NMR and MS.
Appearance:Amorphous powder.
Solubility:Soluble in DMSO or 100% ethanol.
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Total synthesis of dimeric pyrrole-imidazole alkaloids: sceptrin, ageliferin, nagelamide e, oxysceptrin, nakamuric acid, and the axinellamine carbon skeleton: D.P. O'Malley, et al.; J. Am. Chem. Soc. 129, 4762 (2007), Abstract;
Cyclic heptapeptides from the Jamaican sponge Stylissa caribica: R. Mohammed, et al.; J. Nat. Prod. 69, 1739 (2006), Abstract;
New bromopyrrole alkaloids from the Indopacific sponge Agelas nakamurai: C. Eder, et al.; J. Nat. Prod. 62, 1295 (1999), Abstract;
A study on the mechanism of action of sceptrin, an antimicrobial agent isolated from the South Pacific sponge Agelas mauritiana: V.S. Bernan, et al.; J. Antimicrob. Chemother. 32, 539 (1993), Abstract;
Anti-muscarinic activity of a family of C11N5 compounds isolated from Agelas sponges: R. Rosa, et al.; Experientia 48, 885 (1992), Abstract;

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