Biologically active isoflavone. Affects serotonin levels and platelet aggregation in blood cells. 5-HT2c antagonist. Antibacterial. Displays cardioprotective effects. Induces apoptosis.
Product Details
| Alternative Name: | 8-(β-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one, NPI-031G |
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| Formula: | C21H20O9 |
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| MW: | 416.4 |
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| Source: | Isolated from Kudzu root. |
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| CAS: | 3681-99-0 |
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| RTECS: | UO5216000 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Puerarin inhibits proliferation and induces apoptosis in human glioblastoma cell lines: J. Yang, et al.; Int. J. Clin. Exp. Med.
8, 10132 (2015),
Application(s): Effect of puerarin on human glioblastoma cells,
Abstract;
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Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin: 574, 179 (2007) : Q. Gao, et al.; Eur. J. Pharmacol.
574, 179 (2007),
Abstract;
Induction of apoptosis by puerarin in colon cancer HT-29 cells: Z. Yu & W. Li; Cancer Lett.
238, 53 (2006),
Abstract;
Contrasting effects of puerarin and daidzin on glucose homeostasis in mice: E. Meezan, et al.; J. Agric. Food Chem.
53, 8760 (2005),
Abstract;
Puerarin reduces increased c-fos, c-jun, and type IV collagen expression caused by high glucose in glomerular mesangial cells: C.P. Mao & Z.L. Gu; Acta Pharmacol. Sin.
26, 982 (2005),
Abstract;
NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists: D.H. Overstreet, et al.; Pharmacol. Biochem. Behav.
75, 619 (2003),
Abstract;
Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria: W.M. Keung & B.L. Vallee; PNAS
95, 2198 (1998),
Abstract;
Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity: D.H. Kim, et al.; Biol. Pharm. Bull.
21, 628 (1998),
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