Replaces Prod. #: BML-G236
Potent, selective and competitive inhibitor of Ras farnesyltransferase (IC50=30nM). Does not affect geranylgeranyltransferase (IC50=180µM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Inhibits neutral sphingomyelinase. Cell permeable. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19µM).
Product Details
Formula: | C31H38N2O7 |
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MW: | 550.6 |
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Source: | Isolated from Streptomyces parvulus. |
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CAS: | 52665-74-4 |
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Purity: | ≥96% (HPLC) |
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Identity: | Determined by 1H-NMR. |
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Appearance: | Yellow to brown powder. |
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Solubility: | Soluble in methanol or DMSO; insoluble in water. |
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Shipping: | Blue Ice |
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Short Term Storage: | +4°C |
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Long Term Storage: | -20°C |
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Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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Handling: | Protect from light. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
NF-κB Signaling Negatively Regulates Osteoblast Dedifferentiation during Zebrafish Bone Regeneration: R. Mishra, et al.; Dev. Cell
52, 167 (2020),
Application(s): Screening on Juvenile and adult zebrafish,
Abstract;
Pathobiology of renal-specific oxidoreductase/myo-inositol oxygenase in diabetic nephropathy: its implications in tubulointerstitial fibrosis: P. Xie, et al.; Am. J. Physiol. Renal Physiol.
298, F1393 (2010),
Abstract;
Full Text
An HTS approach to screen for antagonists of the nuclear export machinery using high content cell-based assays: F. Zanella, et al.; Assay Drug Dev. Technol.
5, 333 (2007),
Abstract;
Binding of manumycin A inhibits IkappaB kinase beta activity: M. Bernier, et al.; J. Biol. Chem.
281, 2551 (2006),
Abstract;
Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells: M. She, et al.; Leukemia
19, 595 (2005),
Abstract;
Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase: C. Arenz, et al.; ChemBioChem
2, 141 (2001),
Abstract;
Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells: A. Di Paolo, et al.; Br. J. Cancer
82, 905 (2000),
Abstract;
Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes: Y. Zou et al.; J. Biol. Chem.
271, 33592 (1996),
Abstract;
Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic: J.B. Gibbs, et al.; Cell
77, 175 (1994),
Abstract;
Identification of Ras farnesyltransferase inhibitors by microbial screening: M. Hara et al.; PNAS
90, 2281 (1993),
Abstract;
Inhibitors of Ras farnesyltransferases: F. Tamanoi; TIBS
18, 349 (1993), (Review),
Abstract;