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Manumycin A

Ras farnesyltransferase inhibitor



ALX-350-241-M010	10 mg	Inquire for pricing

ALX-350-241-M005	5 mg	Inquire for pricing

ALX-350-241-M001	1 mg	Inquire for pricing
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Replaces Prod. #: BML-G236

Potent, selective and competitive inhibitor of Ras farnesyltransferase (IC₅₀=30nM). Does not affect geranylgeranyltransferase (IC50=180µM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Inhibits neutral sphingomyelinase. Cell permeable. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19µM).

Product Details

Formula:	C₃₁H₃₈N₂O₇

MW:	550.6

Source:	Isolated from Streptomyces parvulus.

CAS:	52665-74-4

Purity:	≥96% (HPLC)

Identity:	Determined by ¹H-NMR.

Appearance:	Yellow to brown powder.

Solubility:	Soluble in methanol or DMSO; insoluble in water.

Shipping:	Blue Ice

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Use/Stability:	Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

Handling:	Protect from light.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

NF-κB Signaling Negatively Regulates Osteoblast Dedifferentiation during Zebrafish Bone Regeneration: R. Mishra, et al.; Dev. Cell 52, 167 (2020), Application(s): Screening on Juvenile and adult zebrafish, Abstract;

Pathobiology of renal-specific oxidoreductase/myo-inositol oxygenase in diabetic nephropathy: its implications in tubulointerstitial fibrosis: P. Xie, et al.; Am. J. Physiol. Renal Physiol. 298, F1393 (2010), Abstract; Full Text

An HTS approach to screen for antagonists of the nuclear export machinery using high content cell-based assays: F. Zanella, et al.; Assay Drug Dev. Technol. 5, 333 (2007), Abstract;

Binding of manumycin A inhibits IkappaB kinase beta activity: M. Bernier, et al.; J. Biol. Chem. 281, 2551 (2006), Abstract;

Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells: M. She, et al.; Leukemia 19, 595 (2005), Abstract;

Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase: C. Arenz, et al.; ChemBioChem 2, 141 (2001), Abstract;

Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells: A. Di Paolo, et al.; Br. J. Cancer 82, 905 (2000), Abstract;

Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes: Y. Zou et al.; J. Biol. Chem. 271, 33592 (1996), Abstract;

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic: J.B. Gibbs, et al.; Cell 77, 175 (1994), Abstract;

Identification of Ras farnesyltransferase inhibitors by microbial screening: M. Hara et al.; PNAS 90, 2281 (1993), Abstract;

Inhibitors of Ras farnesyltransferases: F. Tamanoi; TIBS 18, 349 (1993), (Review), Abstract;