Cephalotaxine alkaloid. Inhibits the formation of diphenylalanine and acetylphenylalanyl-puromycin in liver ribosomes. Has promising activity in hematologic malignancies. Lowers the levels of telomerase. Induces apoptosis.
Product Details
| Formula: | C29H39NO9 |
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| MW: | 545.6 |
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| Source: | Isolated from Cephalotaxus hainanensis. |
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| CAS: | 26833-87-4 |
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| RTECS: | FK0260000 |
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| Purity: | ≥96% (Assay) |
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| Identity: | Determined by NMR. |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Homoharringtonine-induced apoptosis of human leukemia HL-60 cells is associated with down-regulation of telomerase: W.Z. Xie, et al.; Am. J. Chin. Med.
34, 233 (2006),
Abstract;
Homoharringtonine: a new treatment option for myeloid leukemia: C.Y. Luo, et al.; Hematology
9, 259 (2004), Review,
Abstract;
Homoharringtonine: history, current research, and future direction: H.M. Kantarjian, et al.; Cancer
92, 1591 (2001), Review,
Abstract;
Homoharringtonine is safe and effective for patients with acute myelogenous leukemia: E. Feldman, et al.; Leukemia
6, 1185 (1992),
Abstract;
Selective inhibition of the polypeptide chain elongation in eukaryotic cells: R.M. Tujebajeva, et al.; Biochim. Biophys. Acta
1129, 177 (1992),
Abstract;
Different effects of L-histidinol and homoharringtonine on 5- fluorouracil and bis-chloroethylnitrosourea activity in a murine model: R.C. Warrington & W.D. Fang; Anticancer Res.
11, 1879 (1991),
Abstract;
