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Carcinogenesis inhibitor
ALX-350-230-M010 10 mg 286.00 USD
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Potent, selective inducer of phase II detoxification enzymes. Inhibits chemically induced mammary tumor formation in rats.

Product Details

Alternative Name:L-Sulforaphane, (-)-1-Isothiocyanato-(4R)-(methylsulfinyl)butane
Source:Chiral natural product isolated from broccoli.
MI:14: 8962
Purity:≥98% (UHPLC)
Appearance:Slightly yellowish liquid. **Please note this product can be very difficult to see and may present as an almost invisible film.
Solubility:Soluble in methanol, 100% ethanol, DMSO or ethyl acetate.
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Phytochemicals Resveratrol and Sulforaphane as Potential Agents for Enhancing the Anti-Tumor Activities of Conventional Cancer Therapies: B.M. Kaminski, et al.; Curr. Pharm. Biotechnol. 13, 137 (2012), Abstract;
Protective effect of sulforaphane against oxidative stress: Recent advances: C.E. Guerrero-Beltran, et al.; Exp. Toxicol. Pathol. 64, 503 (2012), Abstract;
Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage: P. Bergstrom, et al.; Neuropharmacology 60, 343 (2011), Abstract;
Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53: E. Rudolf & M. Cervinka; Toxicol. In Vitro 25, 1302 (2011), Abstract;
The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer: A.F. Abdull Razis, et al.; Int. J. Cancer 128, 2775 (2011), Abstract;
Sulforaphane induces DNA single strand breaks in cultured human cells: P. Sestili, et al.; Mutat. Res. 689, 65 (2010), Abstract;
Sulforaphane targets pancreatic tumor-initiating cells by NF-{kappa}B-induced anti-apoptotic signaling: G. Kallifatidis, et al.; Gut 58, 949 (2009), Abstract;
Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex: M.L. Kerns, et al.; PNAS 104, 14460 (2007), Abstract;
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase: M.C. Myzak ,et al.; Cancer Res. 64, 5767 (2004), Abstract; Full Text
Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage: X. Gao & P. Talalay; PNAS 101, 10446 (2004), Abstract;
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors: J.W. Fahey, et al.; PNAS 99, 7610 (2002), Abstract; Full Text
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates: Y. Zhang, et al.; PNAS 91, 3147 (1994), Abstract; Full Text
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure: Y. Zhang, et al.; PNAS 89, 2399 (1992), Abstract; Full Text

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