Mycotoxin contaminant of fruit and cereal products. Exhibits antifungal and phytotoxic activity. Has also been shown to possess DNA strand-breaking activity and inhibits the activity of topoisomerase IIα in mammalian cell models.
Product Details
| Alternative Name: | 9-O-Methylalternariol, Djalonensone, AME, 3,7-Dihydroxy-9-methoxy-1-methyl-6H- dibenzo[b,d]pyran-6-one |
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| Formula: | C15H12O5 |
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| MW: | 272.3 |
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| Source: | Isolated from Alternaria sp. |
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| CAS: | 26894-49-5 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | Off-white to light brown solid. |
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| Solubility: | Soluble in methylene chloride, dichloromethane or methanol. |
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| Shipping: | Ambient |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
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| Handling: | After reconstitution protect from light at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Alternariol acts as a topoisomerase poison preferentially affecting the IIα isoform.: M. Fehr et al.; Mol. Nutr. Food Res.
53, 441 (2009),
Abstract;
Analysis of alternariol and alternariol monomethyl ether on flavedo and albedo tissues of tangerines (Citrus reticulata) with symptoms of alternaria brown spot.: R. F. Magnani, et al; J. Agric. Food Chem.
55, 4980 (2007),
Abstract;
Novel oxidative in vitro metabolites of the mycotoxins alternariol and alternariol methyl ether: E. Pfeiffer, et al.; Mol. Nutr. Food Res.
51, 307 (2007),
Abstract;
Evaluation of alternariol and alternariol methyl ether for mutagenic activity in Salmonella typhimurium: V.M. Davis and M.E. Stack; Appl. Environ. Microbiol.
60, 3901 (1994),
Abstract;
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Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay: G.F. Griffin and F.S. Chu; Appl. Environ. Microbiol.
46, 1420 (1983),
Abstract;
Full Text
Light inhibits the production of alternariol and alternariol monomethyl ether in Alternaria alternata: K. Soderhall, et al.; Appl. Environ. Microbiol.
36, 655 (1978),
Abstract;
Full Text
Studies in the biochemistry of micro-organisms. 90. Alternariol and alternariol monomethyl ether, metabolic products of Alternaria tenuis: H. Raistrick, et al.; Biochem. J.
55, 421 (1953),
Abstract;
Full Text
