Inhibits platelet aggregation. Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Shows antifungal activity.
Product Specification
| Alternative Name: | 2’,4’,4-Trihydroxy-3’-[3’’-methylbut-3’’-enyl]chalcone |
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| Formula: | C20H20O4 |
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| MW: | 324.4 |
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| Source: | Isolated from plant Psoralea corylifolia. |
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| CAS: | 20784-50-3 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Determined by 1H-NMR and MS. |
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| Appearance: | Yellow oil. |
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| Solubility: | Soluble in DMSO or 100% ethanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Bavachin and isobavachalcone, acyl-coenzyme A: cholesterol acyltransferase inhibitors from Psoralea corylifolia: J.H. Choi et al.; Arch. Pharm. Res.
31, 1419 (2008),
Abstract;
Inhibition of matrix metalloproteinase-2 secretion by chalcones from the twigs of Dorstenia barteri Bureau.: B. Ngameni, et al.; Arkivoc
ix, 91 (2007),
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Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects: T. Akihisa, et al.; J. Nat. Prod.
69, 38 (2006),
Abstract;
Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa: N.O. Omisore, et al.; Braz. J. Med. Biol. Res.
38, 1087 (2005),
Abstract;
Xanthoangelol, a major chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma and leukemia cells: K. Tabata, et al.; Biol. Pharm. Bull.
28, 1404 (2005),
Abstract;
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects: T. Akihisa, et al.; Cancer Lett.
201, 133 (2003),
Abstract;
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res.
16, 539 (2002),
Abstract;
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod.
59, 671 (1996),
Abstract;
