Inhibitor of protein tyrosine phosphatase 1B (PTB1B). Antioxidant. Inhibitor of mitochondrial lipid peroxidation. Inhibitor of inducible nitric oxide synthase (iNOS; NOS II) expression. DNA polymerase inhibitor. Shows antimicrobial and cytotoxic activity.
Product Details
| Alternative Name: | 4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol |
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| Formula: | C18H24O |
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| MW: | 256.4 |
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| Source: | Isolated from plant Psoralea corylifolia. |
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| CAS: | 10309-37-2 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Determined by 1H-NMR, 13C-NMR and MS. |
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| Appearance: | Yellow to brownish oil. |
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| Solubility: | Soluble in DMSO or 100% ethanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Psoralea corylifolia L. Seed Extract Attenuates Diabetic Nephropathy by Inhibiting Renal Fibrosis and Apoptosis in Streptozotocin-Induced Diabetic Mice: E. Seo, et al.; Nutrients
9, 828 (2017),
Abstract;
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Protective Effect of Psoralea corylifolia L. Seed Extract against Palmitate-Induced Neuronal Apoptosis in PC12 Cells: Y. Lee, et al.; Evid. Based Complement. Alternat. Med.
2016, 5410419 (2016),
Application(s): Cell treatment, seed PC12 extract,
Abstract;
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Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts: E.J. Park, et al.; Eur. J. Pharmacol.
559, 115 (2007),
Abstract;
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia: Y.C. Kim, et al.; Planta Med.
71, 87 (2005),
Abstract;
Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent: K. Bapat, et al.; Appl. Radiat. Isot.
62, 389 (2005),
Abstract;
Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo: E.J. Park, et al.; Planta Med.
71, 508 (2005),
Abstract;
Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain: S. Adhikari, et al.; Chem. Res. Toxicol.
16, 1062 (2003),
Abstract;
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res.
16, 539 (2002),
Abstract;
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis: S.M. Newton, et al.; J. Ethnopharmacol.
79, 57 (2002),
Abstract;
Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities: C.N. Backhouse, et al.; J. Ethnopharmacol.
78, 27 (2001),
Abstract;
Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappaB in RAW 264.7 macrophages: H.O. Pae, et al.; Int. Immunopharmacol.
1, 1849 (2001),
Abstract;
Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells: H. Cho, et al.; Planta Med.
67, 750 (2001),
Abstract;
In vitro antimicrobial activities of bakuchiol against oral microorganisms: H. Katsura, et al.; Antimicrob. Agents Chemother.
45, 3009 (2001),
Abstract;
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Inhibition of mitochondrial lipid peroxidation by Bakuchiol, a meroterpene from Psoralea corylifolia: H. Haraguchi, et al.; Planta Med.
66, 569 (2000),
Abstract;
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod.
61, 362 (1998),
Abstract;
Plant antimutagenic agents, 2. Flavonoids: M.E. Wall, et al.; J. Nat. Prod.
51, 1084 (1988),
Abstract;
