Derivative of rocaglamide (Prod. No. ALX-350-121) with similar pharmacological properties.
Product Details
| Alternative Name: | 1-Acetyl-3’-hydroxyrocaglamide |
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| Formula: | C31H33NO9 |
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| MW: | 563.6 |
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| Source: | Isolated from Aglaia sp. |
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| CAS: | 189322-68-7 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Identity determined by MS, 1H-NMR. |
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| Appearance: | White to off-white sticky solid. |
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| Solubility: | Soluble in DMSO or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull.
54, 1344 (2006),
Abstract;
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem.
6, 319 (2006),
Abstract;
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol.
174, 7075 (2005),
Abstract;
Full Text
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem.
277, 44791 (2002),
Abstract;
Full Text
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod.
64, 415 (2001),
Abstract;
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod.
64, 1216 (2001),
Abstract;
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem.
48, 1400 (2000),
Abstract;
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry
54, 731 (2000),
Abstract;
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982),
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