Potent inhibitor of HIV reverse transcriptase and cellular DNA polymerase. Inhibitor of CDC25A. Similar compounds have shown inhibitory effects on phospholipase A2.
Product Details
| Alternative Name: | HPH |
| |
| Formula: | C36H54O2 |
| |
| MW: | 518.8 |
| |
| Source: | Isolated from Sarcotragus sp. |
| |
| CAS: | 119980-00-6 |
| |
| Purity: | ≥97% (HPLC) |
| |
| Identity: | Determined by MS, 1H-NMR. |
| |
| Appearance: | Off-white to brown solid. May appear as oily solid. |
| |
| Solubility: | Soluble in DMSO or 100% ethanol. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Handling: | Protect from light. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A: I. Erdogan-Orhan, et al.; Nat. Prod. Res.
18, 1 (2004),
Abstract;
Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases: S. Loya, et al.; Biochem. J.
324, 721 (1997),
Abstract;
Full Text
Biological effects of prenylated hydroquinones: structure-activity relationship studies in antimicrobial, brine shrimp, and fish lethality assays: S. De Rosa, et al.; J. Nat. Prod.
57, 1711 (1994),
Abstract;
Three new heptaprenylhydroquinone derivatives from the sponge Ircinia fasciculata: Y. Venkateswarlu & M. Venkata Rami Reddy; J. Nat. Prod.
57, 1286 (1994),
Abstract;
General Literature References
Effects of marine 2-polyprenyl-1,4-hydroquinones on phospholipase A2 activity and some inflammatory responses: B. Gil, et al.; Eur. J. Pharmacol.
285, 281 (1995),
Abstract;
