Dithiodiketopiperazine inhibitor of HIF-1 formation by disrupting the binding of p300 to both HIF-1α and HIF-2α. Inhibitor of tumor growth. Potent immunosuppressor. Antibacterial.
Product Details
| Alternative Name: | Chaetomin |
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| Formula: | C31H30N6O6S4 |
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| MW: | 710.9 |
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| Source: | Isolated from Chaetomium species. |
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| CAS: | 1403-36-7 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | Off-white to fawn solid. |
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| Solubility: | Soluble in DMSO, ethyl acetate or pyridine; fairly soluble in methanol, 100% ethanol; insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Handling: | Following reconstitution in highly pure, anhydrous solvent, aliquot and freeze at -80°C. Protect from light and moisture. Avoid freeze/thaw cycles. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Lipopolysaccharide induces inducible nitric oxide synthase-dependent podocyte dysfunction via a hypoxia-inducible factor 1-alpha and cell division control protein 42 and Ras-related C3 botulinum toxin substrate 1 pathway: A.K. Mashmoushi, et al.; Free Radic. Biol. Med.
84, 185 (2015),
Application(s): Cell Culture,
Abstract;
Hypoxia-inducible factors promote alveolar development and regeneration: A. Vadivel, et al.; Am. J. Respir. Cell Mol. Biol.
50, 96 (2014),
Abstract;
Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells: K. Yano, et al.; Int. J. Oncol.
38, 365 (2011),
Abstract;
Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells: A. Staab, et al.; BMC Cancer
7, 213 (2007),
Abstract;
Full Text
Immunomodulatory constituents from an Ascomycete, Chaetomium seminudum: H. Fujimoto, et al.; J. Nat. Prod.
67, 98 (2004),
Abstract;
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway: A.L. Kung, et al.; Cancer Cell
6, 33 (2004),
Abstract;
Effects of chetomin on growth and acidic fermentation products of rumen bacteria: W.C. Jen and G.A. Jones; Can. J. Microbiol.
29, 1399 (1983),
Abstract;
The structure of chetomin: A.G. McInnes, et al.; JACS
98, 6741 (1976),
Abstract;
