Mycotoxin. Tremorgenic. Potent and specific inhibitor of the breast cancer resistance protein (BCRP; ABCG2). Reverses multidrug resistance mediated by BCRP and increases cytotoxicity of several anticancer agents in vitro.
Product Details
| Alternative Name: | FTC, SM-Q |
| |
| Formula: | C22H25N3O3 |
| |
| MW: | 379.5 |
| |
| Source: | Isolated from Aspergillus fumigatus. |
| |
| CAS: | 118974-02-0 |
| |
| Purity: | ≥96% (HPLC) |
| |
| Identity: | Determined by 1H-NMR. |
| |
| Appearance: | White to light brown powder. |
| |
| Solubility: | Soluble in DMSO, methanol or chloroform. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | +4°C |
| |
| Technical Info/Product Notes: | Optical Rotation: [α]D= +19° ±1° (c=1.0 in methanol). |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma: W.J. Ingram, et al.; Exp. Hematol. Oncol.
2, 26 (2013),
Abstract;
Full Text
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2: K. Takabe, et al.; J. Biol. Chem.
285, 10477 (2010),
Abstract;
Role of P-glycoprotein and breast cancer resistance protein-1 in the brain penetration and brain pharmacodynamic activity of the novel phosphatidylinositol 3-kinase inhibitor GDC-0941: L. Salphati, et al.; Drug. Metab. Dispos.
38, 1422 (2010),
Abstract;
The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells: Y. Ma & M. Wink; Phytother. Res.
24, 146 (2010),
Abstract;
Histone Deacetylase Inhibitors Induce a Very Broad, Pleiotropic Anticancer Drug Resistance Phenotype in Acute Myeloid Leukemia Cells by Modulation of Multiple ABC Transporter Genes: S. Hauswald, et al.; Clin. Cancer Res.
15, 3705 (2009),
Abstract;
Plasma pharmacokinetics and tissue distribution of the breast cancer resistance protein (BCRP/ABCG2) inhibitor fumitremorgin C in SCID mice bearing T8 tumors: T.S. Garimella, et al.; Cancer Chemother. Pharmacol.
55, 101 (2005),
Abstract;
The role of breast cancer resistance protein in acute lymphoblastic leukemia: S.L. Plasschaert, et al.; Clin. Cancer Res.
9, 5171 (2003),
Abstract;
Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation.: Ozvegy, et al.; J. Biol. Chem.
277, 47980 (2002),
Abstract;
Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.: S.K. Rabindran, et al.; Cancer Res.
60, 47 (2000),
Abstract;
Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin: S.K. Rabindran, et al.; Cancer Res.
58, 5850 (1998),
Abstract;
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties: C.B. Cui, et al.; J. Antibiot.
49, 527 (1996),
Abstract;
Mycotoxins produced by Aspergillus fumigatus species isolated from molded silage: R.J. Cole, et al.; J. Agric. Food Chem.
25, 826 (1977),
Abstract;
