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Insulin sensitizing agent
ALX-350-125-M025 25 mg 152.00 USD
ALX-350-125-M100 100 mg 431.00 USD
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Potent insulin sensitizing agent. Peroxisome proliferator-activated receptor γ (PPAR-γ) agonist. Hepatotoxic. Antidiabetic.

Product Details

MI:14: 8265
Purity:≥97% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (>25mg/ml), 100% ethanol or methanol.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Use/Stability:Stable for 2 years after receipt when stored at +4°C. Stock solutions are stable for up to 3 months when stored at -20°C.
Regulatory Status:RUO - Research Use Only
ALX-350-125 structure
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ALX-350-125 structure

Product Literature References

Differential effects of dolutegravir, bictegravir and raltegravir in adipokines and inflammation markers on human adipocytes: P. Domingo, et al.; Life Scienes 308, 120948 (2022), Abstract;
Role of respiratory uncoupling in drug-induced mitochondrial permeability transition: T. Sato, et al.; Toxicol. Appl. Pharmacol. 427, 115659 (2021), Abstract;
A PPAR-gamma agonist protects from radiation-induced intestinal toxicity: M. Mangoni, et al.; United European Gastroenterol. J. 5, 218 (2017), Application(s): Cell culture, Abstract; Full Text
A combination of (+)-catechin and (-)-epicatechin underlies the in vitro adipogenic action of Labrador tea (Rhododendron groenlandicum), an antidiabetic medicinal plant of the Eastern James Bay Cree pharmacopeia: H.M. Eid, et al. ; J. Ethnopharmacol. 178, 251 (2016), Application(s): Cell culture, Abstract;
ECM microenvironment unlocks brown adipogenic potential of adult human bone marrow-derived MSCs: M.H. Lee, et al.; Sci. Rep. 6, 21173 (2016), Application(s): Cell culture, Abstract; Full Text
Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma: H.Y. Lee, et al.; Korean J. Intern. Med. 31, 89 (2016), Application(s): Cell culture, Abstract; Full Text
Effects of alpha-lipoic acid on chemerin secretion in 3 T3-L1 and human adipocytes: P.L. Prieto-Hontoria, et al. ; Biochim. Biophys. Acta 1861, 260 (2016), Application(s): Cell culture, Abstract;
A Novel Peroxisome Proliferator-activated Receptor (PPAR)α Agonist and PPARγ Antagonist, Z-551, Ameliorates High-fat Diet-induced Obesity and Metabolic Disorders in Mice: Y. Shiomi, et al.; J. Biol. Chem. 290, 14567 (2015), Application(s): Cell Culture, Abstract; Full Text
Expression of human and mouse adenine nucleotide translocase (ANT) isoform genes in adipogenesis: A. Gavaldà-Navarro, et al.; Int. J. Biochem. Cell. Biol. 64, 34 (2015), Application(s): Cell Culture, Abstract;
Rosiglitzone Suppresses Angiotensin II-Induced Production of KLF5 and Cell Proliferation in Rat Vascular Smooth Muscle Cells: D. Gao, et al.; PLoS One 10, e0123724 (2015), Application(s): Cell Culture, Abstract; Full Text
Modulation of RAGE and the Downstream Targets of RAGE Signaling Cascades by Taurine in Lycium Barbarum (Goji Berry): Protection of Human Retinal Pigment Epithelial Barrier Function and its Potential Benefit in Diabetic Retinopathy: M.K. Song, et al.; J. Diabetes Metab. 2, 162 (2011), Application(s): Cell Culture, Full Text
A review of rosiglitazone in type 2 diabetes mellitus: A.L. Werner & M.T. Travaglini; Pharmacotherapy 21, 1082 (2001), (Review), Abstract;
Rosiglitazone (Avandia): hepatic, cardiac and hematological reactions: M. McMorran & D. Vu; CMAJ 165, 82 (2001), Abstract;
Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review: J.M. Malinowski & S. Bolesta; Clin. Ther. 22, 1151 (2000), (Review), Abstract;
Rosiglitazone: an agent from the thiazolidinedione class for the treatment of type 2 diabetes: A. Cheng-Lai & A. Levine; Heart Dis. 2, 326 (2000), (Review), Abstract;
Differential effects of insulin-sensitizers troglitazone and rosiglitazone on ion currents in rat vascular myocytes: G.A. Knock, et al.; Eur. J. Pharmacol. 368, 103 (1999), Abstract;
Rosiglitazone: J.A. Balfour & G.L. Plosker; Drugs 57, 921 (1999), (Review) , Abstract;
Differential activity of rosiglitazone enantiomers at PPAR gamma: D.J. Parks, et al.; Bioorg. Med. Chem. Lett. 81, 3657 (1998), Abstract;

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