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NF-κB inhibitor
ALX-350-120-MC05 0.5 mg 439.00 USD
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Potent anti-inflammatory and antineoplastic agent. Induces a CD95 death receptor-independent apoptosis even when the mitochondria protecting proteins Bcl-XLor Bcl-2 are overexpressed. Also an inhibitor of NF-κB.

Product Details

Source:Isolated from Arnica species.
Purity:≥97% (HPLC)
Identity:Determined by NMR.
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (10mg/ml) or 100% ethanol.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Cox-2 Inhibition Protects against Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis via Akt-Dependent Enhancement of iNOS Expression: L. Pang, et al.; Oxid. Med. Cell. Longev. 2016, 3453059 (2016), Application(s): Cell treatment, rat cardiomyocytes , Abstract; Full Text
The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65: G. Lyss, et al; J. Biol. Chem. 273, 33508 (1998), Abstract;
Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB: G. Lyss, et al.; J. Biol. Chem. 378, 951 (1997), Abstract;
Constituents of Helenium species.XIII. The structure of Helenalin and Mexicanin A: W. Herz, et al.; JACS 85, 19 (1963),