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Sibutramine . hydrochloride . monohydrate

Anti-obesity agent
 
ALX-350-111-G001 1 g 77.00 USD
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Anti-obesity agent. Prevents resorption of the messenger substances serotonin and noradrenalin in the brain, allowing them to act at higher concentration on nerve cells and increasing the feeling of satiety.

Product Specification

Alternative Name:1-(4-Chlorophenyl-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine . HCl . H2O
 
Formula:C17H26ClN . HCl . H2O
 
MW:279.9 . 36.5 . 18.0
 
CAS:125494-59-9
 
MI:14: 8485
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white crystalline powder.
 
MeltingPoint:190-201°C
 
Solubility:Soluble in methanol or water (2.9mg/ml at pH 5.2).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Regulatory Status:RUO - Research Use Only
 
350-111
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350-111

Product Literature References

GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve: H. Ueno, et al.; PLoS One 14, e0222653 (2019), Abstract;
SCO-792, an enteropeptidase inhibitor, improves disease status of diabetes and obesity in mice: H.Yashiro, et al.; Diabetes Obes. Metab. (2019), Abstract;
A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models: Y. Kawata, et al.; Eur. J. Pharmacol. 796, 45 (2016), Abstract;

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