Induces differentiation of human HL-60 promyelocytic leukemia cells.
Activates the transcription factor complex AP-1 -mediated expression of secreted alkaline phosphatase in COS-7 cells.
Product Specification
| Alternative Name: | 4-(8-methyl-4,7-dioxo-1,6-dioxaspiro[4.4]nona-2,8-dien-3-yl)cyclohexanecarbaldehyde |
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| Formula: | C15H16O5 |
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| MW: | 276.3 |
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| Source: | Isolated from Nidula candida. |
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| CAS: | 185853-14-9 |
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| Purity: | ≥95% |
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| Appearance: | Lyophilized |
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| Solubility: | Soluble in 100% ethanol, methanol or DMSO. |
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| Shipping: | Shipped on Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. Keep cool and dry. After reconstitution, prepare aliquots and store at -20°C. |
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Product Literature References
Quantifying biogenic bias in screening libraries: J. Hert, et al.; Nat. Chem. Biol.
5, 479 (2009),
Abstract;
Nidulal, a novel inducer of differentiation of human promyelocytic leukemia cells from Nidula candida: G. Erkel, et al.; J. Antibiot.
49, 1189 (1996),
Abstract;
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