Starting material for the synthesis of the antitumor drugs vinblastine and vincristine. It is less active as an inhibitor of tubulin self-assembly into microtubules than the latter two compounds.
Product Details
| Alternative Name: | 3,4-Didehydroibogamine-18-carboxylic acid methyl ester . tartrate, 7-Ethyl-9,10,12,13-tetrahydro-6,9-methano-5H-pyrido[1’,2’:1,2]azepino[4,5-b]indole-6(6aH)-carboxylic acid methyl ester . tartrate |
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| Formula: | C21H24N2O2 . C4H6O6 |
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| MW: | 336.4 . 150.1 |
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| Source: | Isolated from Catharanthus roseus. |
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| CAS: | 4168-17-6 |
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| MI: | 14: 1904 |
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| Purity: | ≥90% (assay on dried basis) |
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| Appearance: | White to off-white crystalline powder. |
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| Solubility: | Soluble in 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Very hygroscopic. Keep cool and dry. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline: V. Prakash & S.N. Timasheff; Biochemistry
30, 873 (1991),
Abstract;
Photochemical one-pot synthesis of vinblastine and vincristine: S. Pennanen & A. Huhtikangas; Photochem. Photobiol.
51, 515 (1990),
Abstract;
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