Potent, naturally occuring non-steroid estrogenic compound. Agonist for estrogen receptor (ER) α and agonist/antagonist for ERβ with higher binding affinity than tamoxifen (Prod. No. ALX-550-095) for both ERs. Electrogenic Ca2+ ionophore inducing mitochondrial depolarisation which can be completely blocked by cyclosporin A (Prod. No. BML-A195), suggesting that ferutinin opens the mitochondrial permeability transition pore (mPTP). In a concentration range of 1-50µM ferutinin increases the permeability of thymocytes, mitochondria, sarcoplasmic reticulum, liposomes and bilayer lipid membranes for Ca2+.
Product Details
| Formula: | C22H30O4 |
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| MW: | 358.5 |
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| Source: | Semisynthetic. |
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| CAS: | 41743-44-6 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid |
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| Solubility: | Soluble in acetone, dichloromethane, DMSO or ethyl acetate. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells: A.Y. Abramov & M.R. Duchen; Cell Calcium
33, 101 (2003),
Abstract;
Daucane phytoestrogens: a structure-activity study: G. Appendino, et al.; J. Nat. Prod.
65, 1612 (2002),
Abstract;
Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER(alpha) and ERbeta: K. Ikeda, et al.; BBRC
291, 354 (2002),
Abstract;
Influence of plant terpenoids on the permeability of mitochondria and lipid bilayers: A.Y. Abramov, et al.; Biochim. Biophys. Acta
1512, 98 (2001),
Abstract;
Ionophoretic properties of ferutinin: M.V. Zamaraeva, et al.; Cell Calcium
22, 235 (1997),
Abstract;
Ferutinine structure: A.I. Saidkhodjaev, et al.; Chem. Nat. Comp. 1, 28 (1973),
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