Inhibitor of EGFR tyrosine kinase with improved bioavailability over lavendustin C.
Product Details
| Alternative Name: | Compound 5 methyl ester, 5-Amino-N-(2,5-dihydroxybenzyl)methyl salicylate |
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| Formula: | C15H15NO5 |
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| MW: | 289.3 |
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| Source: | Synthetic. |
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| Purity: | ≥97% |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in DMSO or methanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Structure-activity relationships in a series of 5-[(2,5- dihydroxybenzyl)amino]salicylate inhibitors of EGF-receptor-associated tyrosine kinase: importance of additional hydrophobic aromatic interactions: H. Chen, et al.; J. Med. Chem.
37, 845 (1994),
Abstract;
Synthesis and structure-activity studies of a series of [(hydroxybenzyl)amino]salicylates as inhibitors of EGF receptor- associated tyrosine kinase activity: H. Chen, et al.; J. Med. Chem.
36, 4094 (1993),
Abstract;
