Replaces Prod. #: BML-EI270
Mitochondrial uncoupler that depolarizes the mitochondrial membrane potential, reduces cellular ATP levels, activates 5‘-AMP-activated protein kinase (AMPK) and affects mitochondrial production of reactive oxygen species (ROS). Potent activator of multiple Ca2+-sensitive K+ channels. Blocks several kinases and non-kinase proteins in vitro. Has been widely-used as a selective inhibitor of protein kinase Cδ (PKCδ) (IC50=3-6µM). Although there is extensive published documentation to support the use of rottlerin as a selective PKCδ inhibitor, there has been some controversy in the literature over this claim. Some of this controversy may arise from the fact that rottlerin is a promiscuous inhibitor and therefore may not always display the same properties as would be expected from a classical 1:1 inhibitor. However, there are studies indicate that rottlerin has no direct effect on PKCδ and that it should not be used to determine the involvement of PKCδ in biological processes. Induces autophagy by inhibition of mTORC1 signaling.
Product Details
| Alternative Name: | Mallotoxin |
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| Formula: | C30H28O8 |
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| MW: | 516.5 |
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| Source: | Isolated from Mallotus philippinensis. |
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| CAS: | 82-08-6 |
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| MI: | 14: 8272 |
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| RTECS: | AM6913800 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Orange to brown solid. |
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| Solubility: | Soluble in DMSO (up to 50mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels: V. Matschke, et al.; Cell Physiol Biochem.
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Abstract;
Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling: A.D. Balgi, et al.; PLOS ONE
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Abstract;
Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis: K.S. Song, et al.; Autophagy
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Abstract;
Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta: S.P. Soltoff; TIPS
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Abstract;
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