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Canavanine . sulfate

iNOS inhibitor
ALX-350-002-M100 100 mg 44.00 USD
ALX-350-002-M500 500 mg 155.00 USD
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The non-protein amino acid L-canavanine is an analog of L-arginine. Selective inducible nitric oxide synthase (iNOS; NOS II) inhibitor. Induces apoptotic cell death and shows antiproliferative and immunotoxic effects.

Product Details

Alternative Name:L-α-Amino-γ-(guanidinooxy)-n-butyric acid . sulfate
Formula:C5H12N4O3 . H2SO4
MW:176.2 . 98.1
MI:14: 1737
Purity:≥99% (TLC)
Identity:Identity determined by IR.
Appearance:White to-off white powder.
Solubility:Soluble in water (100mg/ml).
Shipping:Ambient Temperature
Long Term Storage:+4°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Role of non-protein amino acid L-canavanine in autoimmunity: J. Akaogi, et al.; Autoimmun. Rev. 5, 429 (2006), Abstract;
L-arginine analogs as alternate substrates for nitric oxide synthase: S.D. Luzzi & M.A. Marletta; Bioorg. Med. Chem. Lett. 15, 3934 (2005), Abstract;
Comparative effects of vasopressin, norepinephrine, and L-canavanine, a selective inhibitor of inducible nitric oxide synthase, in endotoxic shock: B. Levy, et al.; Am. J. Physiol. Heart Circ. Physiol. 287, H209 (2004), Abstract; Full Text
L-Canavanine as a radiosensitization agent for human pancreatic cancer cells: A.K. Bence, et al.; Mol. Cell Biochem. 244, 37 (2003), Abstract;
Arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via caspase-3 activation regulated by Bcl-2 or Bcl-xL: M.H. Jang, et al.; BBRC 295, 283 (2002), Abstract;
Effect of L-canavanine, an Inhibitor of inducible nitric oxide synthase, on myocardial dysfunction during septic shock: N. Suzuki, et al.; J. Nippon Med. Sch. 69, 13 (2002), Abstract; Full Text
The antiproliferative and immunotoxic effects of L-canavanine and L-canaline: A.K. Bence, et al.; Anticancer Drugs 13, 313 (2002), Abstract;
L-canavanine, a selective inhibitor of inducible NO synthase, increases plasma endothelin-1 concentrations in dogs with endotoxic shock: C. Mitaka, et al.; J. Crit. Care 16, 17 (2001), Abstract;
Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain: H.M. Abd El-Gawad & A.E. Khalifa; Pharmacol. Res. 43, 257 (2001), Abstract;
Beneficial effects of L-canavanine, a selective inhibitor of inducible nitric oxide synthase, on lactate metabolism and muscle high energy phosphates during endotoxic shock in rats: B. Levy, et al.; Shock 11, 98 (1999), Abstract;
L-Canavanine modulates cellular growth, chemosensitivity and P-glycoprotein substrate accumulation in cultured human tumor cell lines: D.R. Worthen, et al.; Cancer Lett. 132, 229 (1998), Abstract;
Beneficial effects of L-canavanine, a selective inhibitor of inducible nitric oxide synthase, during rodent endotoxaemia: L. Liaudet, et al.; Clin. Sci. (London) 90, 369 (1996), Abstract;
Effects of L-canavanine, an inhibitor of inducible nitric oxide synthase, on endotoxin mediated shock in rats: Z. Fatehi-Hassanabad, et al.; Shock 6, 194 (1996), Abstract;
Inhibition of nitric oxide formation with L-canavanine attenuates endotoxin-induced vascular hyporeactivity in the rat: M. Cai, et al.; Eur. J. Pharmacol. 295, 215 (1996), Abstract;
Inhibition of the growth of human pancreatic cancer cells by the arginine antimetabolite L-canavanine: D.S. Swaffar, et al.; Cancer Res. 54, 6045 (1994), Abstract;