The non-protein amino acid L-canavanine is an analog of L-arginine. Selective inducible nitric oxide synthase (iNOS; NOS II) inhibitor. Induces apoptotic cell death and shows antiproliferative and immunotoxic effects.
Product Details
| Alternative Name: | L-α-Amino-γ-(guanidinooxy)-n-butyric acid . sulfate |
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| Formula: | C5H12N4O3 . H2SO4 |
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| MW: | 176.2 . 98.1 |
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| CAS: | 2219-31-0 |
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| MI: | 14: 1737 |
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| Purity: | ≥99% (TLC) |
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| Identity: | Identity determined by IR. |
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| Appearance: | White to-off white powder. |
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| Solubility: | Soluble in water (100mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Role of non-protein amino acid L-canavanine in autoimmunity: J. Akaogi, et al.; Autoimmun. Rev.
5, 429 (2006),
Abstract;
L-arginine analogs as alternate substrates for nitric oxide synthase: S.D. Luzzi & M.A. Marletta; Bioorg. Med. Chem. Lett.
15, 3934 (2005),
Abstract;
Comparative effects of vasopressin, norepinephrine, and L-canavanine, a selective inhibitor of inducible nitric oxide synthase, in endotoxic shock: B. Levy, et al.; Am. J. Physiol. Heart Circ. Physiol.
287, H209 (2004),
Abstract;
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L-Canavanine as a radiosensitization agent for human pancreatic cancer cells: A.K. Bence, et al.; Mol. Cell Biochem.
244, 37 (2003),
Abstract;
Arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via caspase-3 activation regulated by Bcl-2 or Bcl-xL: M.H. Jang, et al.; BBRC
295, 283 (2002),
Abstract;
Effect of L-canavanine, an Inhibitor of inducible nitric oxide synthase, on myocardial dysfunction during septic shock: N. Suzuki, et al.; J. Nippon Med. Sch.
69, 13 (2002),
Abstract;
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The antiproliferative and immunotoxic effects of L-canavanine and L-canaline: A.K. Bence, et al.; Anticancer Drugs
13, 313 (2002),
Abstract;
L-canavanine, a selective inhibitor of inducible NO synthase, increases plasma endothelin-1 concentrations in dogs with endotoxic shock: C. Mitaka, et al.; J. Crit. Care
16, 17 (2001),
Abstract;
Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain: H.M. Abd El-Gawad & A.E. Khalifa; Pharmacol. Res.
43, 257 (2001),
Abstract;
Beneficial effects of L-canavanine, a selective inhibitor of inducible nitric oxide synthase, on lactate metabolism and muscle high energy phosphates during endotoxic shock in rats: B. Levy, et al.; Shock
11, 98 (1999),
Abstract;
L-Canavanine modulates cellular growth, chemosensitivity and P-glycoprotein substrate accumulation in cultured human tumor cell lines: D.R. Worthen, et al.; Cancer Lett.
132, 229 (1998),
Abstract;
Beneficial effects of L-canavanine, a selective inhibitor of inducible nitric oxide synthase, during rodent endotoxaemia: L. Liaudet, et al.; Clin. Sci. (London)
90, 369 (1996),
Abstract;
Effects of L-canavanine, an inhibitor of inducible nitric oxide synthase, on endotoxin mediated shock in rats: Z. Fatehi-Hassanabad, et al.; Shock
6, 194 (1996),
Abstract;
Inhibition of nitric oxide formation with L-canavanine attenuates endotoxin-induced vascular hyporeactivity in the rat: M. Cai, et al.; Eur. J. Pharmacol.
295, 215 (1996),
Abstract;
Inhibition of the growth of human pancreatic cancer cells by the arginine antimetabolite L-canavanine: D.S. Swaffar, et al.; Cancer Res.
54, 6045 (1994),
Abstract;
