Ins (1,4,5)P3 derivative with a cage on position 4, which does not show biological activity until photochemical destruction of the cage. A short light pulse (254 or 360nm) releases active Ins(1,4,5)P3 within a second, thus mimicking the rapid responses of the receptor/phospholipase C signalling system in the cell. Since this approach does not (directly) trigger other signalling events, for instance protein kinase C (PKC) activation after receptor-mediated diacylglycerol (DAG) formation, these molecules are exciting tools to help dissect signalling pathways. This photolabile derivative of Ins(1,4,5)P3 is not metabolized by endogenous phosphatase (extinction coefficient: 4240M-1cm-1; 265nm, water).
Product Specification
| Alternative Name: | Ins(1,4,5)P3 (caged) . 3Na, D-myo-Inositol 1,4,5-trisphosphate, P4-1-(2-nitrophenyl)ethyl ester . 3Na |
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| Formula: | C14H19NO17P3 . 3Na |
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| MW: | 566.2 . 69.0 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light and moisture. |
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Product Literature References
Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphate: J.W. Walker, et al.; Nature
327, 249 (1987),
Abstract;
