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1,2-Di-O-butyryl-D-myo-inositol 3,4,5,6-tetrakisphosphate octakis(propionoxymethyl)ester

ALX-307-063-1 1 Vial 464.00 USD
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Cell permeable derivative of Prod. No. ALX-307-061.

Product Details

Alternative Name:Bt2Ins(3,4,5,6)P4/PM
Purity:≥98% (HPLC)
Identity:Identity determined by 1H-NMR, 31P-NMR and MS.
Appearance:Clear syrup.
Solubility:Soluble in toluene and DMSO.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Use/Stability:Do not freeze mixtures of Pluronic®, DMSO and inositolphosphates!
Handling:Protect from moisture.
Technical Info/Product Notes:Includes 1 vial of 10% Pluronic® (F127) solution in DMSO.
Protocol:Recommendations on application (Cuvette Experiments)
- Prepare a 100mM stock solution by adding 20µl of DMSO to 1µmol of inositol product.
- In a fresh vial mix 1µl of the stock solution and 2µl of Pluronic® as supplied.
- Add 500µl of your cell suspension and mix carefully.
- Add this mixture to the remaining cell suspension (~500µl) and mix carefully.
Note: Cell suspension should not contain more than 1% of DMSO.
Regulatory Status:RUO - Research Use Only
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Product Literature References

myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell line: M.A. Carew, et al.; J. Biol. Chem. 275, 26906 (2000), Abstract; Full Text
Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4: M. Vajanaphanich, et al.; Nature 371, 711 (1994), Abstract;

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