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1,2-Di-O-butyryl-D-myo-inositol 3,4,5,6-tetrakisphosphate octakis(propionoxymethyl)ester



ALX-307-063-1	1 Vial	464.00 USD
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Cell permeable derivative of Prod. No. ALX-307-061.

Product Details

Alternative Name:	Bt₂Ins(3,4,5,6)P₄/PM

Formula:	C₄₆H₇₆O₃₆P₄

MW:	1329.0

Quantity:	1µmol

Purity:	≥98% (HPLC)

Identity:	Identity determined by ¹H-NMR, ³¹P-NMR and MS.

Appearance:	Clear syrup.

Solubility:	Soluble in toluene and DMSO.

Shipping:	Shipped on Blue Ice

Long Term Storage:	-20°C

Use/Stability:	Do not freeze mixtures of Pluronic^®, DMSO and inositolphosphates!

Handling:	Protect from moisture.

Technical Info/Product Notes:	Includes 1 vial of 10% Pluronic^® (F127) solution in DMSO.

Protocol:	Recommendations on application (Cuvette Experiments) - Prepare a 100mM stock solution by adding 20µl of DMSO to 1µmol of inositol product. - In a fresh vial mix 1µl of the stock solution and 2µl of Pluronic^® as supplied. - Add 500µl of your cell suspension and mix carefully. - Add this mixture to the remaining cell suspension (~500µl) and mix carefully. Note: Cell suspension should not contain more than 1% of DMSO.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell line: M.A. Carew, et al.; J. Biol. Chem. 275, 26906 (2000), Abstract; Full Text

Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4: M. Vajanaphanich, et al.; Nature 371, 711 (1994), Abstract;

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