Uncouples chloride secretion from the Ca2+ signal. Reduces Cl- secretion.
Product Details
| Alternative Name: | Ins(3,4,5,6)P4 . 8Na |
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| Formula: | C6H8O18P4 . 8Na |
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| MW: | 492.0 . 183.9 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Identity determined by 1H-NMR, 31P-NMR and MS. |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell line: M.A. Carew, et al.; J. Biol. Chem.
275, 26906 (2000),
Abstract;
Full Text
Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4: M. Vajanaphanich, et al.; Nature
371, 711 (1994),
Abstract;
