The presence of 4,5-bisphosphate group on the inositol ring has been found critical for binding specifically to PH domains that are commonly present in signalling proteins, also found in cytoskeleton.
Product Details
| Alternative Name: | PtdIns(4,5)P2, (1,2-dipalmitoyl)-, L-α-Phosphatidyl-(1,2-dipalmitoyl)-D-myo-inositol 4,5-bisphosphate |
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| Formula: | C41H81O19P3 |
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| MW: | 971.0 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Identity determined by 1H-NMR and 31P-NMR and MS. |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water, DMSO or methanol. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light and moisture. Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5- bisphosphate: R. Rohatgi, et al.; J. Cell Biol.
150, 1299 (2000),
Abstract;
Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking: T.F. Martin; Annu. Rev. Cell. Dev. Biol.
14, 231 (1998), (Review),
Abstract;
The synthesis and cellular roles of phosphatidylinositol 4,5- bisphosphate: A. Toker; Curr. Opin. Cell Biol.
10, 254 (1998),
Abstract;
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate: T.F. Franke, et al.; Science
275, 665 (1997),
Abstract;
Inositolpolyphosphates and their binding proteins--a short review: B. Huisamen & A. Lochner; Mol. Cell. Biochem.
157, 229 (1996),
Abstract;
Structure of the binding site for inositol phosphate in a PH domain: M. Hyvonen, et al.; EMBO J.
14, 4676 (1995),
Abstract;
