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D-myo-Inositol 4,5-bisphosphate, L-α-Phosphatidyl-(1,2-dipalmitoyl)-

ALX-307-039-C100 100 µg 121.00 USD
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The presence of 4,5-bisphosphate group on the inositol ring has been found critical for binding specifically to PH domains that are commonly present in signalling proteins, also found in cytoskeleton.

Product Details

Alternative Name:PtdIns(4,5)P2, (1,2-dipalmitoyl)-, L-α-Phosphatidyl-(1,2-dipalmitoyl)-D-myo-inositol 4,5-bisphosphate
Purity:≥98% (HPLC)
Identity:Identity determined by 1H-NMR and 31P-NMR and MS.
Appearance:White to off-white powder.
Solubility:Soluble in water, DMSO or methanol.
Shipping:Blue Ice
Long Term Storage:-20°C
Handling:Protect from light and moisture. Hygroscopic.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5- bisphosphate: R. Rohatgi, et al.; J. Cell Biol. 150, 1299 (2000), Abstract;
Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking: T.F. Martin; Annu. Rev. Cell. Dev. Biol. 14, 231 (1998), (Review), Abstract;
The synthesis and cellular roles of phosphatidylinositol 4,5- bisphosphate: A. Toker; Curr. Opin. Cell Biol. 10, 254 (1998), Abstract;
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate: T.F. Franke, et al.; Science 275, 665 (1997), Abstract;
Inositolpolyphosphates and their binding proteins--a short review: B. Huisamen & A. Lochner; Mol. Cell. Biochem. 157, 229 (1996), Abstract;
Structure of the binding site for inositol phosphate in a PH domain: M. Hyvonen, et al.; EMBO J. 14, 4676 (1995), Abstract;

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